Polymer conjugates of therapeutic peptides
US-2016022828-A1 · Jan 28, 2016 · US
Polymer conjugates of protegrin peptides
US9763995B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9763995-B2 |
| Application number | US-201514821138-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 7, 2015 |
| Priority date | Sep 19, 2008 |
| Publication date | Sep 19, 2017 |
| Grant date | Sep 19, 2017 |
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- Title
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- Abstract
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Abstract
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The invention provides peptides that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water-soluble oligomer.
First claim
Opening claim text (preview).
What is claimed is: 1. A conjugate of formula: wherein PRO is a protegrin moiety having an amino acid sequence that is at least 90% identical to SEQ ID NO: 1 and each mPEG has a weight average molecular weight in a range of from about 500 Daltons to about 100,000 Daltons. 2. The conjugate of claim 1 , wherein each mPEG has a weight-average molecular weight in a range of from about 500 Daltons to about 80,000 Daltons. 3. The conjugate of claim 1 , wherein each mPEG has a weight-average molecular weight in a range of from about 2000 Daltons to about 50,000 Daltons. 4. The conjugate of claim 1 , wherein each mPEG has a weight-average molecular weight in a range of from about 5000 Daltons to about 40,000 Daltons. 5. A pharmaceutical composition comprising a conjugate of claim 1 and a pharmaceutically acceptable excipient. 6. The conjugate of claim 1 , wherein the protegrin moiety has an amino acid sequence that is at least 95% identical to SEQ ID NO: 1. 7. The conjugate of claim 1 , wherein the protegrin moiety has the amino acid sequence of SEQ ID NO: 1. 8. A method for making a conjugate of claim 1 comprising contacting, under conjugation conditions, a protegrin moiety with a polymeric reagent bearing a functional group. 9. A method of treatment of a microbial infection comprising administering a conjugate of claim 1 to a subject in need thereof.
Assignees
Inventors
Classifications
- A61K38/10Primary
Peptides having 12 to 20 amino acids {(A61K38/043 - A61K38/046 take precedence)} · CPC title
having 12 to 20 amino acids (gastrins C07K14/595; somatostatins C07K14/655; melanotropins C07K14/68) · CPC title
Antibacterial agents · CPC title
the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol · CPC title
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics · CPC title
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- What does patent US9763995B2 cover?
- The invention provides peptides that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water-soluble oligomer.
- Who is the assignee on this patent?
- Nektar Therapeutics
- What technology area does this patent fall under?
- Primary CPC classification A61K38/10. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Sep 19 2017 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 1 related publication on this page (citations in our corpus or others sharing the same primary CPC).