Composition for reducing senescence of cell or subject including BRAF inhibitor and use thereof

Patent metadata

Field	Value
Publication number	US-9763923-B2
Application number	US-201615144463-A
Country	US
Kind code	B2
Filing date	May 2, 2016
Priority date	Apr 30, 2015
Publication date	Sep 19, 2017
Grant date	Sep 19, 2017

Abstract

Provided is a method of reducing senescence in a cell or subject, or treating or preventing a symptom or disease associated therewith, by administering a BRAF inhibitor to the cell or subject.

First claim

What is claimed is:

1. A method of reducing cellular senescence of a skin cell, comprising administering an effective amount of a BRAF inhibitor to the skin cell, wherein the BRAF inhibitor is SB590885, vemurafib, TAK-632, a pharmaceutically acceptable salt, stereomer, or solvate thereof, or a combination thereof.

2. The method of claim 1 , wherein the skin cell is in a subject, and the method comprises administering the BRAF inhibitor to the subject.

3. The method of claim 1 , wherein the administration is topical or systemic administration.

4. The method of claim 1 , wherein the administration is topical administration to skin.

5. The method of claim 1 , wherein the BRAF inhibitor is an agent inhibiting BRAF protein activity.

6. The method of claim 1 , wherein reducing the cellular senescence of the skin cell comprises increasing cell proliferation, decreasing β-galactosidase activity, decreasing lipofuscin accumulation, decreasing formation of reactive oxygen species by mitochondria, or a combination thereof.

7. The method of claim 2 , wherein the subject is afflicted by skin wrinkling, slow scar regeneration, degenerative alopecia, osteoporosis, sarcopenia, progeria, lysosome storage disease, or a combination thereof, caused by cellular senescence.

8. The method of claim 2 , wherein the subject is afflicted with a disease caused by lipofuscin accumulation.

9. The method of claim 1 , wherein the skin cell is a fibroblast.

Assignees

• Samsung Electronics Co Ltd

Inventors

• Keum Jungwon
• Park Joontae
• Jung Chulwon
• Park Sangchul
• Lee Youngsam

Classifications

• A61K31/428

  condensed with carbocyclic rings · CPC title

• A61K31/4439 Primary

  containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole (nicotine A61K31/465) · CPC title

• A61K8/00

  Cosmetics or similar toiletry preparations · CPC title

• A61K31/437

  the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline · CPC title

• A61K8/66

  Enzymes · CPC title