Multicompartmentalized material for the thermostimulated delivery of substances of interest, preparation method thereof and uses of the same

Patent metadata

Field	Value
Publication number	US-9763862-B2
Application number	US-201314409710-A
Country	US
Kind code	B2
Filing date	Jun 20, 2013
Priority date	Jun 21, 2012
Publication date	Sep 19, 2017
Grant date	Sep 19, 2017

Abstract

A material in the form of solid particles with a diameter varying from 10 μm to 1 cm is provided, composed of a continuous solid shell having at least one silicon oxide, said shell imprisoning an aqueous phase The aqueous phase includes at least one hydrophilic substance of interest S H and at least one droplet of a fatty phase predominantly having a crystallizable oil in the solid state at the storage temperature of said material The crystallizable oil has a melting point (T M ) of less than 100° C. and including at least one lipophilic substance of interest S L .

First claim

The invention claimed is:

1. Material in the form of solid particles with a diameter varying from 10 μm to 1 cm which are composed of a continuous solid shell comprising:
at least one silicon oxide, said shell imprisoning an aqueous phase, wherein said aqueous phase includes at least one hydrophilic substance of interest S H and at least one droplet of a fatty phase comprising from 50% to 99.9% by weight, with respect to the weight of said fatty phase, of a crystallizable oil in the solid state at the storage temperature of said material, said crystallizable oil having a melting point (T M ) of less than 100° C. and including at least one lipophilic substance of interest S L , wherein said substances of interest are selected from the group consisting of antiseptics, antibiotics, anti-inflammatories, local laxatives, hormones, proteins, vitamins, sunscreens, antioxidants, agents for combating free radicals, superoxide dismutase, fragrances, odor absorbers, deodorant agents, antiperspirant agents, dyes, pigments, emollients, moisturizing agents, pH indicators, catalysts, polymerization initiators, monomers, and complexing agents.

2. Material according to claim 1 , wherein the crystallizable oil is chosen from fatty substances and mixtures of fatty substances, of natural or synthetic origin, the melting point of which is greater than 15° C. and less than 100° C.

3. Material according to claim 1 , wherein the crystallizable oil is a paraffin wax.

4. Material according to claim 1 , wherein said material is provided in the form of a powder of spherical or substantially spherical particles.

5. Material according to claim 1 , wherein the diameter of the droplet or droplets of fatty phase present in each particle of the material varies from 8 μm to 80 μm.

6. Material according to claim 1 , wherein each particle of material comprises only a single droplet of fatty phase in the aqueous phase present in the silica shell and the volume of said droplet of fatty phase represents from 30% to 70% of the internal volume of the particles.

7. Material according to claim 1 , wherein the silica shell has a thickness of 0.1 to 2 μm.

8. Material according to claim 1 , wherein the silica shell additionally comprises one or more metal oxides of the formula ZrO 2 .

9. Material according to claim 1 , wherein the substance or substances of interest S L represent from 0.001% to 50% by weight of the total weight of the fatty phase present in the aqueous phase.

10. Material according to claim 1 , wherein the substance or substances of interest S H represent from 0.001% to 50% by weight of the weight of the aqueous phase.

11. Pharmaceutical, cosmetic or food products, wherein they include, as ingredient, at least one material as defined in claim 1 .

Assignees

• Centre Nat Rech Scient

Inventors

• Schmitt Veronique
• Nollet Maxime
• Depardieu Martin
• Backov Renal

Classifications

• A61K2800/412

  Microsized, i.e. having sizes between 0.1 and 100 microns · CPC title

• A61K8/31

  Hydrocarbons · CPC title

• A61K8/361

  Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof · CPC title

• C09B67/0097

  Dye preparations of special physical nature; Tablets, films, extrusion, microcapsules, sheets, pads, bags with dyes · CPC title

• Y10T428/2993

  Silicic or refractory material containing [e.g., tungsten oxide, glass, cement, etc.] · CPC title