Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise

Patent metadata

Field	Value
Publication number	US-9763609-B2
Application number	US-201313732848-A
Country	US
Kind code	B2
Filing date	Jan 2, 2013
Priority date	Jul 25, 2003
Publication date	Sep 19, 2017
Grant date	Sep 19, 2017

Abstract

Systems and methods of use involving sensors having a signal-to-noise ratio that is substantially unaffected by non-constant noise are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted.

First claim

What is claimed is:

1. An electrochemical continuous glucose sensor configured for implantation in a host, the glucose sensor comprising:
an electrode configured to measure a signal indicative of a glucose concentration of a host, wherein the signal comprises a glucose-related component and a non-glucose related component; and
an enzyme-containing membrane covering at least a portion of the electrode, wherein the enzyme-containing membrane comprises an outer domain comprising a discontinuously hydrophilic surface, wherein the outer domain is formed from a blend, wherein the outer domain comprises at least about 5 wt. % of a hydrophilic component;
wherein the glucose sensor has a sensitivity to glucose of from about 25 pA/mg/dL to about 500 pA/mg/dL.

2. The glucose sensor of claim 1 , wherein the membrane comprises a fluorocarbon-based material.

3. The glucose sensor of claim 1 , wherein the hydrophilic polymer is a copolymer of poly(ethylene oxide) and poly(propylene oxide).

4. The glucose sensor of claim 1 , wherein the discontinuously hydrophilic outer domain comprises a polyurethane-based domain that has been surface-treated with a polymer containing hydrophilic moieties.

5. The glucose sensor of claim 1 , wherein the outer domain comprises at least about 15 wt. % of a hydrophilic component.

6. The glucose sensor of claim 1 , wherein the outer domain comprises at least about 25 wt. % of a hydrophilic component.

7. The glucose sensor of claim 1 , wherein the glucose sensor has a sensitivity to glucose of from about 25 pA/mg/dL to about 100 pA/mg/dL.

8. The glucose sensor of claim 1 , wherein the glucose sensor comprises an enzyme configured to react with glucose.

Assignees

• Dexcom Inc

Inventors

• Simpson Peter C
• Boock Robert J
• Petisce James R
• Brister Mark C
• Rixman Monica A
• Woo Kum Ming
• Nguyen Lisa
• Brunner Seth R
• Chee Arthur
• Nicholas Melissa A
• Wightlin Matthew D
• Pryor Jack
• Markovic Dubravka

Classifications

• A61B5/7203

  for noise prevention, reduction or removal · CPC title

• A61B5/6848

  Needles · CPC title

• A61B5/14546

  for measuring analytes not otherwise provided for, e.g. ions, cytochromes · CPC title

• A61B5/14865 Primary

  invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors · CPC title

• A61B5/14532

  for measuring glucose, e.g. by tissue impedance measurement · CPC title