Device and method for in vivo flow cytometry using the detection of photoacoustic waves
US-9217703-B2 · Dec 22, 2015 · US
US9759655B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9759655-B2 |
| Application number | US-201514870425-A |
| Country | US |
| Kind code | B2 |
| Filing date | Sep 30, 2015 |
| Priority date | Sep 30, 2014 |
| Publication date | Sep 12, 2017 |
| Grant date | Sep 12, 2017 |
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Laser-based spectroscopy systems and methods including a laser source that emits a beam of radiation, an optical resonant cavity having at least two cavity mirrors, and at least one beam filtering element positioned along a path of the beam external to the cavity and having a front surface, wherein the front surface is oriented such that an intersection of the beam and the surface is at an angle, such as the Brewster's angle or a pseudo-Brewster's, that reduces or eliminates reflection of a predominant polarization component of the beam by the filtering element.
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What is claimed: 1. A laser-based spectroscopy system, the system comprising: a laser source that emits a beam of radiation; an optical resonant cavity having at least two cavity mirrors; and at least one beam filtering element positioned along a path of the beam external to the cavity and having a front surface, wherein the front surface is oriented such that an intersection of the beam and the surface is at an angle that reduces or eliminates reflection of a predominant polarization component of the beam by the filtering element. 2. The system of claim 1 , wherein the laser source is a diode laser source. 3. The system of claim 1 , wherein the at least one beam filtering element comprises an absorptive glass material. 4. The system of claim 3 , wherein the angle is at a pseudo-Brewster angle. 5. The system of claim 1 , wherein the angle is at a Brewster angle. 6. The system of claim 1 , comprising at least two beam filtering elements, each positioned along a path of the beam and having a front surface, wherein each said front surface is oriented such that an intersection of the beam and said front surface is at an angle that reduces reflection of a predominant polarization component of the beam by said surface. 7. The system of claim 1 , wherein the at least one beam filtering element is positioned to receive light reflected off of one of said cavity mirrors. 8. The system of claim 1 , wherein the at least one beam filtering element is positioned to receive light emerging from one of said cavity mirrors. 9. The system of claim 1 , wherein the at least one beam filtering element comprises a neutral density filter. 10. The system of claim 1 , further comprising a second beam filtering element positioned to interact with light reflected from the at least one beam filtering element. 11. An apparatus for detecting one or more analyte species present in a gaseous or liquid medium, the apparatus comprising: a resonant optical cavity having at least two cavity mirrors, one of which is a cavity coupling mirror; a laser that emits a beam of laser light; mode matching optics configured to couple the beam of laser light to the cavity via the cavity coupling mirror; a detector configured to measure an intensity of intracavity optical power of light circulating in the cavity and to generate a signal representing the intracavity optical power of light circulating in the cavity; and a first beam stop element positioned external to the resonant optical cavity and arranged such that an intersection of the beam and a front surface of the first beam stop element is at an angle that reduces or eliminates reflection of a predominant polarization component of the beam by the first beam stop element. 12. The apparatus of claim 11 , wherein the laser is a diode laser. 13. The apparatus of claim 11 , wherein the first beam stop element comprises an absorptive glass material, and wherein the angle is at a pseudo-Brewster angle. 14. The apparatus of claim 11 , wherein the angle is at a Brewster angle. 15. The apparatus of claim 11 , wherein the first beam stop element is positioned to receive light reflected off of one of said at least two cavity mirrors. 16. The apparatus of claim 11 , wherein the first beam stop element is positioned to receive light emerging from one of said at least two cavity mirrors. 17. The apparatus of claim 11 , wherein the first beam stop element comprises a neutral density filter. 18. The apparatus of claim 11 , further comprising a second beam stop element positioned to interact with light reflected from the first beam stop element.
involving the reflection of light at a particular angle of incidence, e.g. Brewster's angle · CPC title
for frequency filtering · CPC title
Measuring characteristics or properties thereof (measuring techniques per se G01J, G01K, G01N, G01R) · CPC title
in gases · CPC title
Neutral density filters · CPC title
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