Separating composite liquids

Patent metadata

Field	Value
Publication number	US-9758764-B2
Application number	US-201414182534-A
Country	US
Kind code	B2
Filing date	Feb 18, 2014
Priority date	Feb 18, 2013
Publication date	Sep 12, 2017
Grant date	Sep 12, 2017

Abstract

Described are embodiments that include methods and devices for separating composite liquids into components. Embodiments involve the use of a flexible membrane for separating a composite liquid into components. The composite liquid may include, in embodiments, a cellular containing liquid, such as whole blood or components of whole blood. In one specific embodiment, the composite liquid is a buffy coat.

First claim

What is claimed is:

1. A separation chamber comprising:
a side wall defining a chamber volume, wherein a plurality of steps on the side wall assists in creating a saturated platelet bed trapping white blood cells from a buffy coat;
a flexible membrane located in the chamber volume and defining a membrane volume, wherein the flexible membrane is designed to expand to contact the inside surface of the side wall and maintain the step design by having corresponding steps on its interior surface, the flexible membrane also designed to contract to return to its original shape, the flexible membrane improving the recovery of white blood cells from a buffy coat;
an inlet port in fluid communication with the membrane volume; and
an outlet port in fluid communication with the membrane volume.

2. The separation chamber of claim 1 , wherein the flexible membrane expands when a volume of composite liquid, including platelets and white blood cells is transferred into the membrane volume.

3. The separation chamber of claim 1 , wherein the flexible membrane expands and contacts an inside surface of the side wall when subjected to a first centrifugal force.

4. The separation chamber of claim 1 , further comprising a cap that engages a top of the side wall and further defines the chamber volume.

5. The separation chamber of claim 1 , wherein the outlet port is in the cap.

6. The separation chamber of claim 1 , wherein the inlet port is in the cap.

7. The separation chamber of claim 1 , wherein the inlet port is fluidly connected to a blood processing vessel.

8. The separation chamber of claim 1 , further comprising a one-way valve fluidly connected to the inlet port and, wherein the one-way valve allows a flow of composite liquid, including platelets and white blood cells, into the membrane volume.

9. The separation chamber of claim 1 , further comprising an inlet tube in fluid communication with the inlet and extending into the membrane volume.

10. The separation chamber of claim 1 , wherein the flexible membrane comprises an outer surface with a cylindrical shape.

11. The separation chamber of claim 1 , wherein the flexible membrane has a thickness that tapers along its length.

Assignees

• Terumo Bct Inc

Inventors

• Ladtkow James R
• Uhl Geoffrey M
• Kolenbrander Jeremy P
• Stanton Briden Ray

Classifications

• A61M1/3616

  Batch-type treatment · CPC title

• A61M1/26

  {and internal elements} which are moving · CPC title

• C12N5/0641 Primary

  Erythrocytes · CPC title

• A61M1/3696

  with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation · CPC title

• A61M1/30

  Single needle dialysis {; Reciprocating systems, alternately withdrawing blood from and returning it to the patient, e.g. single-lumen-needle dialysis or single needle systems for hemofiltration or pheresis} · CPC title