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US-2024390271-A1 · Nov 28, 2024 · US
Muteins of α1m lipocalin and method of production therefor
US9758554B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9758554-B2 |
| Application number | US-201314375188-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jan 31, 2013 |
| Priority date | Jan 31, 2012 |
| Publication date | Sep 12, 2017 |
| Grant date | Sep 12, 2017 |
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Abstract
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The present disclosure relates to a collection of novel muteins derived from human α1m (or a1m) polypeptide or a functional homolog thereof. The disclosure further refers to a α1m mutein capable of specifically binding to one or more targets other than a target to which wild-type α1m binds. The disclosure also relates to a method for producing such collection of muteins and a method for isolating a mutein capable of binding one or more such non-natural targets of wild-type α1m polypeptide. These aspects are made possible due to, e.g, the structural elucidation of α1m disclosed herein by the present inventors, an appreciation of ligand-binding sights thereof and, hence, an understanding of which amino acid positions are most suitable for mutagenesis for re-engineering specificity and affinity for any given target while maintaining the secondary and/or tertiary structure of a1m.
First claim
Opening claim text (preview).
The invention claimed is: 1. A composition comprising at least 100 different muteins of human a1m polypeptide, wherein the amino acid sequence of each mutein differs from human a1m polypeptide at one or more of the sequence positions which correspond to the sequence positions in the four peptide loops #1, #2, #3 and #4 of human a1m polypeptide, wherein the amino acid sequence of each mutein differs from human a1m polypeptide at one or more of the sequence positions which correspond…
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Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
- C07K14/47Primary
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
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- What does patent US9758554B2 cover?
- The present disclosure relates to a collection of novel muteins derived from human α1m (or a1m) polypeptide or a functional homolog thereof. The disclosure further refers to a α1m mutein capable of specifically binding to one or more targets other than a target to which wild-type α1m binds. The disclosure also relates to a method for producing such collection of muteins and a method for isolati…
- Who is the assignee on this patent?
- Univ Muenchen Tech
- What technology area does this patent fall under?
- Primary CPC classification C07K14/47. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Sep 12 2017 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).