Sulfamoylbenzamide derivatives as antiviral agents against HBV infection

Patent metadata

Field	Value
Publication number	US-9758477-B2
Application number	US-201514975239-A
Country	US
Kind code	B2
Filing date	Dec 18, 2015
Priority date	Jul 1, 2011
Publication date	Sep 12, 2017
Grant date	Sep 12, 2017

Abstract

The present invention provides sulfamoylbenzamide derivatives, and pharmaceutical compositions thereof. In certain embodiments, the compounds and pharmaceutical compositions of the invention inhibit pregenomic RNA encapsidation. In other embodiments, the compounds and pharmaceutical compositions of the invention are useful for treating Hepatitis B virus (HBV) infection.

First claim

What is claimed is:

1. A pharmaceutical composition comprising at least one pharmaceutically acceptable carrier, at least one compound of formula (III):

wherein:
R 10 is selected from the group consisting of H, CH 3 , Cl and Br;
R y is selected from the group consisting of

or a pharmaceutically acceptable salt thereof,

and at least one additional agent that treats Hepatitis B virus (HBV) infection.

2. A pharmaceutical composition comprising at least one pharmaceutically acceptable carrier, at least one compound selected from the group consisting of:
3-(Azepane-1-sulfonyl)-N-benzyl-4-chloro-benzamide,
N-Benzyl-4-chloro-3-(piperidine-1-sulfonyl)-benzamide,
N-Benzyl-4-methyl-3-(4-methyl-piperidine-1-sulfonyl)-benzamide,
N-Benzyl-3-benzylsulfamoyl-4-methyl-benzamide,
3-(3-Benzylcarbamoyl-benzenesulfonylamino)-benzoic acid,
N-Benzyl-4-bromo-3-diethylsulfamoyl-benzamide,
any pharmaceutically acceptable salt thereof, and any mixtures thereof; and at least one additional agent that treats Hepatitis B virus (HBV) infection.

Assignees

• Univ Drexel
• Baruch S Blumberg Inst

Inventors

• Guo Ju-Tao
• Xu Xiaodong
• Block Timothy M

Classifications

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P31/14

  for RNA viruses · CPC title

• A61P31/20

  for DNA viruses · CPC title

• A61K31/5375

  1,4-Oxazines, e.g. morpholine · CPC title

• C07D307/68

  Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen · CPC title