Electroporation of tissue products
US-2015343101-A1 · Dec 3, 2015 · US
US9758268B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9758268-B2 |
| Application number | US-201414901349-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jun 19, 2014 |
| Priority date | Jun 25, 2013 |
| Publication date | Sep 12, 2017 |
| Grant date | Sep 12, 2017 |
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Official abstract text for this publication.
The invention relates to a method for sterilizing packaging material, comprising an emitter that is adapted to emit charge carriers, in particular electrons, wherein the charge carriers form at least one cloud, and wherein the emitter and the packaging material are moved relative to each other so that a flow of a gaseous medium is established in between the emitter and the packaging material. The method comprises the steps of: controlling a movement profile between the emitter and the packaging material; sterilizing the flow of the medium in between the emitter and the packaging material by adjusting the movement profile so that the flow of the medium in between the emitter and the packaging material is sterilized. Also disclosed is a device for sterilizing packaging material.
Opening claim text (preview).
The invention claimed is: 1. Method for sterilizing packaging material through use of an emitter that is to emit charge carriers forming at least one cloud, the method comprising: relatively moving the emitter and the packaging material to produce a flow of a gaseous medium that enters a gap between the emitter and the packaging material; controlling a movement profile between the emitter and the packaging material; and sterilizing, by the at least one cloud, the entire flow of the gaseous medium that enters the gap between the emitter and the packaging material by adjusting the movement profile. 2. Method according to claim 1 , wherein the packaging material is tube-shaped packaging material possessing an opening that opens into an interior of the tube-shaped packaging material, and wherein the emitter is operated to sterilize at least the interior of the tube-shaped packaging material through the opening of the tube-shaped packaging material. 3. Method according to claim 2 , comprising performing mutual relative movement between the emitter and the tube-shaped packaging material, during which mutual relative movement a portion of the emitter is temporarily inserted through the opening of the tube-shaped packaging material to sterilize the interior of the packaging material. 4. Method according to claim 3 , wherein the tube-shaped packaging material extends along an axis, the method comprising providing a cloud large enough to at least cover an inner cross section of the tube-shaped packaging material, said inner cross section being perpendicular to the axis, and adjusting the movement profile such that the cloud forms an aseptic barrier in the tube-shaped packaging material that sterilizes any inflow of the gaseous medium between the emitter and the tube-shaped packaging material before the gaseous medium reaches a sterilized interior of the tube-shaped packaging material. 5. Method according to claim 3 , comprising: inserting the emitter into the tube-shaped packaging material to create an outflow of the medium out of the tube-shaped packaging material through the opening, pulling the emitter out of the tube-shaped packaging material to create an inflow of the medium into the tube shaped packaging material, and adapting an inflow-speed and an outflow-speed of the medium using the movement profile. 6. Method according to claim 5 , wherein the movement profile comprises at least a first position at which the emitter and the opening of the tube shaped packaging material are on a common level, and a second position at which the emitter is located in the interior of the tube-shaped packaging material, the method comprising: adjusting the movement profile so that a time span for moving from the first position to the second position, defined as run-in, is shorter than a time span for moving from the second position to the first position, defined as run-out. 7. Method according to claim 5 , wherein the movement profile comprises at least a first position and a second position, the emitter comprising an electron exit window, the method comprising: positioning the electron exit window of the emitter and the opening of the tube-shaped packaging material at a common level at the first position of the movement profile, positioning the electron exit window of the emitter in the interior of the of the tube-shaped packaging material at the second position of the movement profile, adjusting the movement profile so that a time span for moving from the first position to the second position is shorter than a time span for moving from the second position to the first position. 8. Method according to claim 3 , comprising pulling the emitter out of the tube-shaped packaging material to create an inflow of the medium into the tube-shaped packaging material, and adapting an inflow-speed of the medium, using the movement profile, such that the inflow of the medium into the tube-shaped packaging material is sterilized by the cloud, the cloud thereby forming an aseptic barrier. 9. Method according to claim 2 , comprising: creating overpressure in the interior of the tube shaped packaging material to prevent inflow of the medium from coming into the tube shaped packaging material. 10. Method according to claim 1 , wherein the tube-shaped packaging material extends along an axis, wherein the cloud possesses a width that extends perpendicular to the axis, and wherein the cloud possesses a length that extends along the axis, the method comprising: providing a power supply configured to influence the width and the length of the cloud; and operating the power supply so that the width of the cloud covers at least an area between the emitter and the packaging material. 11. Method according to claim 10 , comprising: adapting the length and/or the width of the cloud during run-out when the emitter is outside the packaging material to cover the opening of the packaging material with the cloud. 12. Method according to claim 11 , comprising: lowering and/or stopping a speed of the run-out when the emitter is above the opening; and sterilizing the inflow of the medium. 13. Method according to claim 1 , comprising: adapting an energy level of the charge carriers and/or a dose rate of the emitter as a function of a flow-speed of the medium in between the emitter and the packaging material. 14. Method according to claim 1 , wherein the method comprises: moving the packaging material along the axis through operation of drive unit to produce the movement profile. 15. Device for sterilizing packaging material, comprising: an emitter configured to emit charge carriers forming at least one cloud, the emitter and the packaging material being movable relative to each other so that a flow of a gaseous medium enters a gap between the emitter and the packaging material, a control unit configured to control a movement profile between the emitter and the packaging material to sterilize the entire flow of the gaseous medium that enters the gap between the emitter and the packaging material by the at least one cloud, by adjusting the movement profile. 16. Method for sterilizing packaging material through use of an emitter that is adapted to emit charge carriers forming at least one cloud, the packaging material being a tube-shaped packaging material possessing an opening that opens into an interior of the tube-shaped packaging material, the method comprising: relatively moving the emitter and the tube-shaped packaging material to temporarily introduce a portion of the emitter into the interior of the tube-shaped packaging material by way of the opening of the tube-shaped packaging material and emitting the charge carriers into the interior of the tube-shaped packaging material to sterilize the interior of the tube-shaped packaging material; relatively moving the emitter and the tube-shaped packaging material to remove the emitter from the interior of the tube-shaped packaging material and also create an inflow of gaseous medium into the interior of the tube-shaped packaging material, the gaseous medium being different from the charge carriers; controlling a movement profile between the emitter and the tube-shaped packaging material; sterilizing, by the at least one cloud, the inflow of the gaseous medium into the interior of the tube-shaped packaging material by adapting an inflow-speed of the gaseous medium using the movement profile, the cloud thereby forming an aseptic barrier. 17. Method according to claim 16 , wherein the relatively moving the emitter and the tube-shaped packagi
Particle radiation, e.g. electron-beam, alpha or beta radiation · CPC title
Means for controlling sterilisation processes, data processing, presentation and storage means, e.g. sensors, controllers, programs · CPC title
Plasma, i.e. ionised gases · CPC title
by irradiation · CPC title
Apparatus for generating biocidal substances, e.g. vaporisers, UV lamps · CPC title
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