Fluid injection

Patent metadata

Field	Value
Publication number	US-9757698-B2
Application number	US-201013379782-A
Country	US
Kind code	B2
Filing date	Jun 25, 2010
Priority date	Jun 26, 2009
Publication date	Sep 12, 2017
Grant date	Sep 12, 2017

Abstract

The present invention generally relates to systems and methods for the control of fluids and, in some cases, to systems and methods for flowing a fluid into and/or out of other fluids. As examples, fluid may be injected into a droplet contained within a fluidic channel, or a fluid may be injected into a fluidic channel to create a droplet. In some embodiments, electrodes may be used to apply an electric field to one or more fluidic channels, e.g., proximate an intersection of at least two fluidic channels. For instance, a first fluid may be urged into and/or out of a second fluid, facilitated by the electric field. The electric field, in some cases, may disrupt an interface between a first fluid and at least one other fluid. Properties such as the volume, flow rate, etc. of a first fluid being urged into and/or out of a second fluid can be controlled by controlling various properties of the fluid and/or a fluidic droplet, for example curvature of the fluidic droplet, and/or controlling the applied electric field.

First claim

What is claimed is:

1. A microfluidic apparatus, comprising:
a first microfluidic channel;
a second microfluidic channel contacting the first microfluidic channel at an intersection defined by the first and second microfluidic channels, wherein the second microfluidic channel connects to the intersection via an orifice having a dimension of no more than about 90% of the average cross-sectional dimension of the second microfluidic channel, and wherein the orifice of the second microfluidic channel is sized to create a fluid interface between a fluid in the second microfluidic channel and a fluid in the first microfluidic channel having a radius of curvature that is smaller than the radius of curvature of a first droplet contained within the first microfluidic channel, the radius of curvature of the first droplet being defined in part by the cross-sectional dimension of the first microfluidic channel and the radius of curvature of a second droplet being defined in part by the cross-sectional dimension of the orifice of the second microfluidic channel;
first and second electrodes positioned on opposing sides of the first microfluidic channel and the second microfluidic channel to create an electric field maximum within the intersection; and
a controller configured to control voltage applied to the first and second electrodes to control fluid flow from the second microfluidic channel into the first microfluidic channel.

2. The apparatus of claim 1 , wherein the first microfluidic channel, the second microfluidic channel, the first electrode, and the second electrode are positioned such that a plane intersects each of these.

3. The apparatus of claim 1 , wherein the second microfluidic channel is substantially parallel the first microfluidic channel prior to the intersection.

4. The apparatus of claim 1 , wherein the first microfluidic channel is substantially linear through the intersection with the second microfluidic channel.

5. The apparatus of claim 1 , wherein the first microfluidic channel is defined in a first planar material, and the second microfluidic channel is defined in a second planar material.

6. The apparatus of claim 5 , wherein the orifice is defined at a location where the first planar material and the second planar material physically contact each other.

7. The apparatus of claim 1 , wherein the second microfluidic channel contacts the first microfluidic channel at a T-junction intersection.

8. The apparatus of claim 1 , wherein the microfluidic apparatus further comprises a pressure source configured to vary pressure of a fluid within the second microfluidic channel.

9. The apparatus of claim 1 , wherein the orifice has an average cross-sectional dimension less than about 30 microns.

10. The apparatus of claim 1 , wherein the second microfluidic channel is tapered at the intersection with the first microfluidic channel.

11. The apparatus of claim 1 , wherein the first microfluidic channel contains the first droplet.

12. A microfluidic apparatus, comprising:
a first microfluidic channel;
a second microfluidic channel contacting the first microfluidic channel at an intersection defined by the first and second microfluidic channels, wherein the second microfluidic channel connects to the intersection via an orifice having a dimension of no more than about 90% of the average cross-sectional dimension of the second microfluidic channel, and wherein the orifice of the second microfluidic channel is sized to create a fluid interface between a fluid in the second microfluidic channel and a fluid in the first microfluidic channel having a radius of curvature that is smaller than the radius of curvature of a first droplet contained within the first microfluidic channel, the radius of curvature of the first droplet being defined in part by the cross-sectional dimension of the first microfluidic channel and the radius of curvature of a second droplet being defined in part by the cross-sectional dimension of the orifice of the second microfluidic channel;
first and second electrodes positioned on the same side of the first microfluidic channel to create an electric field maximum within the intersection; and
a controller configured to control voltage applied to the first and second electrodes to control fluid flow from the second microfluidic channel into the first microfluidic channel.

13. The apparatus of claim 12 , wherein the second microfluidic channel contacts the first microfluidic channel at a T-junction intersection.

14. The apparatus of claim 12 , wherein the microfluidic apparatus further comprises a pressure source configured to vary pressure of a fluid within the second microfluidic channel.

15. The apparatus of claim 12 , wherein the orifice has an average cross-sectional dimension less than about 30 microns.

16. The apparatus of claim 12 , wherein the second microfluidic channel is tapered at the intersection with the first microfluidic channel.

17. The apparatus of claim 12 , wherein the first microfluidic channel contains the first droplet.

18. A method, comprising:
providing a microfluidic apparatus comprising a first microfluidic channel and a second microfluidic channel contacting the first microfluidic channel at an intersection defined by the first and second microfluidic channels, wherein the second microfluidic channel connects to the intersection via an orifice having a dimension of no more than about 90% of the average cross-sectional dimension of the second microfluidic channel, and wherein the orifice of the second microfluidic channel is sized to create a fluid interface between a fluid in the second microfluidic channel and a fluid in the first microfluidic channel having a radius of curvature that is smaller than the radius of curvature of a first droplet contained within the first microfluidic channel, the radius of curvature of the first droplet being defined in part by the cross-sectional dimension of the first microfluidic channel and the radius of curvature of a second droplet being defined in part by the cross-sectional dimension of the orifice of the second microfluidic channel;
flowing a droplet through the first microfluidic channel towards an electric field maximum within the intersection, the electric field maximum created by first and second electrodes positioned on opposing sides of the first microfluidic channel and the second microfluidic channel; and
controlling flow of fluid from the second microfluidic channel into the droplet using a controller configured to control voltage applied to the first and second electrodes.

Assignees

• Weitz David A
• Abate Adam R
• Hung Tony
• Mary Pascaline
• Harvard College

Inventors

• Weitz David A
• Abate Adam R
• Hung Tony
• Mary Pascaline

Classifications

• B01L3/50273

  characterised by the means or forces applied to move the fluids · CPC title

• G01N2035/1034

  Transferring microquantities of liquid · CPC title

• B01L3/502784

  specially adapted for droplet or plug flow, e.g. digital microfluidics · CPC title

• F16K99/0042

  Electric operating means therefor · CPC title

• Y10T137/206

  Flow affected by fluid contact, energy field or coanda effect [e.g., pure fluid device or system] · CPC title