Biomaterial and methods of use thereof for the prevention of post-operative adhesions

Patent metadata

Field	Value
Publication number	US-9757499-B2
Application number	US-201414569199-A
Country	US
Kind code	B2
Filing date	Dec 12, 2014
Priority date	Jun 12, 2012
Publication date	Sep 12, 2017
Grant date	Sep 12, 2017

Abstract

Biofunctional films and methods of use thereof for the prevention of post-operative adhesions are disclosed.

First claim

What is claimed is:

1. A method of preventing post-surgical adhesions in a patient in need thereof comprising: providing a complex of polyeletrolytes (PEC), comprising a mixture of polycationic chitosan and polyanionic polygalacturonic acid (PGA) in the form of a dry film;
introducing said dry film into a surgical site, said dry film being effective to separate healing tissues, and maintaining said dry film post-operatively at said surgical site for a period of at least seven days.

2. The method of claim 1 , wherein said dry film comprises a mixture of chitosan and polygalacturonic acid in a ratio of 1:1 by weight, or a ratio in which the weight percent of polyanionic PGA exceeds the weight percent of polycationic chitosan in said dry film, thereby imparting an overall negative charge to said film.

3. The method of claim 2 , wherein said dry film comprises a mixture of chitosan and polygalacturonic acids in a ratio of 40:60 by weight.

4. The method of claim 3 wherein said dry film has a thickness between 75-250 microns.

5. The method of claim 4 , wherein said dry film has a thickness of about 100 microns.

6. The method of claim 4 , wherein said dry film has a thickness of about 180 microns.

7. The method of claim 1 , wherein said complex of polyeletrolytes exhibits anti-inflammatory properties.

8. The method of claim 1 , wherein the surgical site is produced from cardiosurgery, articular surgery, abdominal surgery, thoracic surgery, surgery in the urogenital region, nerve surgery, tendon surgery, laparascopic surgery, pelvic surgery, oncological surgery, sinus and craniofacial surgery, ENT surgery, ophthalmological surgery, or a procedure involving spinal dura repair.

9. The method of claim 1 , wherein the dry film is preformed prior to contacting the surgical site.

10. The method of claim 2 , wherein said complex of polyeletrolytes further comprises pectin or dextran sulphate.

11. The method of claim 10 , wherein said complex of polyeletrolytes comprises chitosan-polygalacturonic acid-pectin.

12. The method of claim 11 , wherein said complex of polyeletrolytes comprises about 40% chitosan, about 55% polygalacturonic acid and about 5% pectin.

13. The method of claim 10 , wherein said complex of polyeletrolytes comprises chitosan-galacturonic acid-dextran sulphate.

14. The method of claim 13 , wherein said complex of polyeletrolytes comprises about 40% chitosan, about 40% galacturonic acid and about 20% dextran sulphate.

15. A method of preventing post-surgical adhesions in a patient in need thereof comprising: providing a complex of polyeletrolytes (PEC), comprising a mixture of polycationic chitosan and polyanionic polygalacturonic acid (PGA);
introducing said mixture into said surgical, said mixture forming a film at said site, said film being effective to separate healing tissues, and maintaining said film post-operatively at said surgical site for a period of at least seven days.

Assignees

• Univ Rutgers

Inventors

• Langrana Noshir
• Verma Devendra
• Previtera Michelle

Classifications

• A61L31/042 Primary

  Polysaccharides · CPC title

• C08J2305/08

  Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof · CPC title

• C08J2305/00

  Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2301/00 or C08J2303/00 · CPC title

• C08L5/08

  Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof · CPC title

• C08J5/18

  Manufacture of films or sheets · CPC title