Piperidinone derivatives as MDM2 inhibitors for the treatment of cancer
US-9593129-B2 · Mar 14, 2017 · US
Calcium propane-2-sulfinate dihydrate
US9757367B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9757367-B2 |
| Application number | US-201615175821-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jun 7, 2016 |
| Priority date | Jun 10, 2013 |
| Publication date | Sep 12, 2017 |
| Grant date | Sep 12, 2017 |
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- Title
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- Abstract
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Abstract
Official abstract text for this publication.
The present invention provides processes for making 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid as well as intermediates and processes for making the intermediates. Also provided are crystalline forms of the compound and the intermediates.
First claim
Opening claim text (preview).
What is claimed is: 1. A compound, wherein the compound is 2. A process of making the compound of claim 1 , wherein the process comprises reacting propane-2-sulfinic acid with calcium acetate to form the compound of claim 1 .
Assignees
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Classifications
Ortho-condensed systems · CPC title
- C07D211/94Primary
Oxygen atom, e.g. piperidine N-oxide · CPC title
Sulfinic acids; Derivatives thereof · CPC title
- A61K31/451Primary
having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine · CPC title
the oxygen-containing ring being five-membered · CPC title
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- What does patent US9757367B2 cover?
- The present invention provides processes for making 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid as well as intermediates and processes for making the intermediates. Also provided are crystalline forms of the compound and the intermediates.
- Who is the assignee on this patent?
- Amgen Inc
- What technology area does this patent fall under?
- Primary CPC classification C07D211/94. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Sep 12 2017 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 12 related publications on this page (citations in our corpus or others sharing the same primary CPC).