Dosimetric method

Patent metadata

Field	Value
Publication number	US-9753145-B2
Application number	US-201415029429-A
Country	US
Kind code	B2
Filing date	Oct 28, 2014
Priority date	Oct 28, 2013
Publication date	Sep 5, 2017
Grant date	Sep 5, 2017

Abstract

The present invention relates to a method for detecting and optionally quantifying exposure to ionizing radiation and applications thereof. More particularly, the invention relates to the detection and/or quantification of ionizing radiation exposure by detecting the colour change of one or more dianhydrohexitol compounds, such as isosorbide, caused by ionizing radiation. It also relates to the use of dianhydrohexitol compounds for detecting exposure to irradiation, to a system and kit that may be used for such purposes, and to a method for making sterilized objects, which also relies on the colour change induced by ionizing radiation.

First claim

The invention claimed is:

1. A method for detecting and optionally quantifying exposure to ionizing radiation, comprising the steps:
(a) providing a dianhydrohexitol or dianhydrohexitol-containing composition, wherein the dianhydrohexitol is one or more of isosorbide, isomannide and isoidide;
(b) exposing the dianhydrohexitol or dianhydrohexitol-containing composition to ionizing radiation, thereby effecting a colour change in the dianhydrohexitol;
(c) detecting the colour change in the dianhydrohexitol or dianhydrohexitol-containing composition; and optionally
(d) quantifying the dose of ionizing radiation absorbed by the dianhydrohexitol or dianhydrohexitol-containing composition on the basis of the colour change.

2. The method according to claim 1 , wherein detecting the colour change is performed visually and the method further comprises the step of quantifying the dose of ionizing radiation by comparing the colour change with a reference to determine (i) if a pre-defined minimum exposure has occurred and optionally (ii) the quantity of exposure that has occurred.

3. The method according to claim 2 , wherein the exposed dianhydrohexitol or dianhydrohexitol-containing composition is dissolved in a solvent and the step of detecting the colour change is performed on a solution of the exposed dianhydrohexitol or dianhydrohexitol-containing composition.

4. The method according to claim 2 , wherein the dianhydrohexitol is isosorbide.

5. The method according to claim 1 , wherein detecting the colour change is performed with a colorimetric , chromometric or spectrometric device and the method further comprises the step of quantifying the dose of ionizing radiation by comparing the colour change with a reference to determine (i) if a pre-defined minimum exposure has occurred and optionally (ii) the quantity of exposure that has occurred.

6. The method according to claim 5 , wherein the exposed dianhydrohexitol or dianhydrohexitol-containing composition is dissolved in a solvent and the step of detecting the colour change is performed on a solution of the exposed dianhydrohexitol or dianhydrohexitol-containing composition.

7. The method according to claim 5 , wherein the dianhydrohexitol is isosorbide.

8. The method according to claim 5 , wherein the colorimetric device is a UV-vis spectrometer.

9. The method according to claim 8 , wherein the exposed dianhydrohexitol or dianhydrohexitol-containing composition is dissolved in a solvent and the step of detecting the colour change is performed on a solution of the exposed dianhydrohexitol or dianhydrohexitol-containing composition.

10. The method according to claim 8 , wherein the dianhydrohexitol is isosorbide.

11. The method according to claim 1 , wherein the exposed dianhydrohexitol or dianhydrohexitol-containing composition is dissolved in a solvent and the step of detecting the colour change is performed on a solution of the exposed dianhydrohexitol or dianhydrohexitol-containing composition.

12. The method according to claim 11 , wherein the dianhydrohexitol is isosorbide.

13. The method according to claim 1 , wherein the dianhydrohexitol is isosorbide.

14. The method according to claim 1 , wherein the ionizing radiation is X-ray or γ-ray.

15. A method for detecting and optionally quantifying exposure to ionizing radiation, comprising the steps:
(a) providing a dianhydrohexitol or dianhydrohexitol-containing composition, wherein the dianhydrohexitol is one or more of isosorbide, isomannide and isoidide;
(b) exposing the dianhydrohexitol or dianhydrohexitol-containing composition to ionizing radiation, thereby producing a free radical;
(c) detecting a free radical in the dianhydrohexitol or dianhydrohexitol-containing composition by electron paramagnetic resonance (EPR); and optionally
(d) quantifying the dose of ionizing radiation absorbed by the dianhydrohexitol or dianhydrohexitol-containing composition on the basis of the EPR signal.

16. The method according to claim 15 , wherein the dianhydrohexitol is isosorbide.

17. A system for detecting and optionally quantifying exposure to ionizing radiation comprising:
a dianhydrohexitol; and
a means to determine if (i) the dianhydrohexitol has been exposed to a pre-defined dose of ionizing radiation and optionally (ii) the quantity of the exposure that has occurred.

18. A kit comprising:
a dianhydrohexitol or dianhydrohexitol-containing composition, wherein the dianhydrohexitol is one or more of isosorbide, isomannide and isoidide; and
a means to determine if (i) the dianhydrohexitol or dianhydrohexitol-containing composition has been exposed to a pre-defined dose of ionizing radiation and optionally (ii) the quantity of the exposure that has occurred.

19. A kit according to claim 18 , which is for determining whether an object has been effectively sterilized, wherein the means is a colour chart and pre-defined dose of ionizing radiation is the minimum dosage required for effective sterilization.

20. A kit according to claim 19 , wherein the pre-defined dose of ionizing radiation is 5 kGy or higher, preferably 20 kGy or higher, more preferably 25 kGy or higher.

Assignees

• Nitto Denko Corp

Inventors

• De Visscher Geofrey
• Schüwer Nicolas

Classifications

• G01T1/04 Primary

  Chemical dosimeters (G01T1/06, G01T1/08 take precedence) · CPC title