Modular fabrication systems and methods
US-9242031-B2 · Jan 26, 2016 · US
Self-assembling cell aggregates and methods of making engineered tissue using the same
US9752116B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9752116-B2 |
| Application number | US-201615235422-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 12, 2016 |
| Priority date | Feb 24, 2004 |
| Publication date | Sep 5, 2017 |
| Grant date | Sep 5, 2017 |
How to read this patent
A practical reading order for non-experts. Skip the full description unless you need deep technical detail.
- Title
What the patent document calls the invention.
- Abstract
A short plain-language summary of the technical disclosure.
- Assignees and inventors
Who owns or filed the patent and who is credited as inventor.
- Key dates
Filing, priority, publication, and grant dates set the timeline.
- First independent claim
The legal scope of protection — read this for what is actually claimed.
- CPC / IPC classifications
Technology tags used to group this patent with similar filings.
- Citations and related patents
Prior art links and similar publications in this corpus.
Abstract
Official abstract text for this publication.
A composition comprising a plurality of cell aggregates for use in the production of engineered organotypic tissue by organ printing. A method of making a plurality of cell aggregates comprises centrifuging a cell suspension to form a pellet, extruding the pellet through an orifice, and cutting the extruded pellet into pieces. Apparatus for making cell aggregates comprises an extrusion system and a cutting system. In a method of organ printing, a plurality of cell aggregates are embedded in a polymeric or gel matrix and allowed to fuse to form a desired three-dimensional tissue structure. An intermediate product comprises at least one layer of matrix and a plurality of cell aggregates embedded therein in a predetermined pattern. Modeling methods predict the structural evolution of fusing cell aggregates for combinations of cell type, matrix, and embedding patterns to enable selection of organ printing processes parameters for use in producing an engineered tissue having a desired three-dimensional structure.
First claim
Opening claim text (preview).
What is claimed is: 1. A method of producing a tissue construct, comprising depositing cell aggregates from a dispensing device, and allowing the cell aggregates to fuse. 2. The method of claim 1 , wherein the cell aggregates are dispensed in a pattern. 3. The method of claim 1 , wherein the cell aggregates are homocellular. 4. The method of claim 1 , wherein the cell aggregates are heterocellular. 5. The method of claim 1 , wherein the dispensing device is instructed by a control unit.
Assignees
Inventors
Classifications
Products made by additive manufacturing · CPC title
for controlling or regulating additive manufacturing processes · CPC title
- C12N5/0062Primary
General methods for three-dimensional culture · CPC title
Artificial constructs associating cells of different lineages, e.g. tissue equivalents (blood vessels C12N5/0691) · CPC title
Processes of additive manufacturing · CPC title
Patent family
Related publications grouped by family.
External sources
Frequently asked questions
Answers are generated from the same data shown on this page.
- What does patent US9752116B2 cover?
- A composition comprising a plurality of cell aggregates for use in the production of engineered organotypic tissue by organ printing. A method of making a plurality of cell aggregates comprises centrifuging a cell suspension to form a pellet, extruding the pellet through an orifice, and cutting the extruded pellet into pieces. Apparatus for making cell aggregates comprises an extrusion system a…
- Who is the assignee on this patent?
- Univ Missouri, Musc Found For Res Dev
- What technology area does this patent fall under?
- Primary CPC classification C12N5/0062. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Sep 05 2017 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 11 related publications on this page (citations in our corpus or others sharing the same primary CPC).