Surface-modified elastic body

Patent metadata

Field	Value
Publication number	US-9752003-B2
Application number	US-201314077829-A
Country	US
Kind code	B2
Filing date	Nov 12, 2013
Priority date	Nov 30, 2012
Publication date	Sep 5, 2017
Grant date	Sep 5, 2017

Abstract

Provided are surface-modified elastic bodies (e.g. gasket for syringes) each obtained by a surface modification method for modifying a rubber vulcanizate or a thermoplastic elastomer, the method being capable of providing surfaces with excellent properties such as excellent sliding properties, excellent durability against repeated sliding motion, and excellent performance in preventing adsorption and aggregation of proteins, and allowing the surfaces to maintain the sealing properties, without using expensive self-lubricating plastics. The invention relates to surface-modified elastic bodies (e.g. gasket for syringes) at least partially having a surface modified by a surface modification method including: step 1 of forming polymerization initiation points on a surface of an object to be modified that includes a rubber vulcanizate or thermoplastic elastomer, and step 2 of radically polymerizing a monomer containing a C—N bond in a molecule thereof, starting from the polymerization initiation points, to grow polymer chains on the surface of the object.

First claim

The invention claimed is:

1. A gasket for syringes which comprises a halogenated butyl rubber, wherein the gasket has a surface at least partially modified by a surface modification method comprising:
step 1 of forming polymerization initiation points on the gasket surface, and
step 2 of radically polymerizing a monomer containing a C—N bond in a molecule thereof, starting at the polymerization initiation points, so as to grow polymer chains on the gasket surface.

2. A low protein adsorption material which comprises a halogenated butyl rubber, wherein the low protein adsorption material has a surface at least partially modified by a surface modification method comprising:
step 1 of forming polymerization initiation points on the low protein adsorption material surface, and
step 2 of radically polymerizing a monomer containing a C—N bond in a molecule thereof, starting at the polymerization initiation points, so as to grow polymer chains on the low protein adsorption material surface.

3. The low protein adsorption material according to claim 2 , wherein the polymerization initiation points are formed by adsorbing a polymerization initiator on the low protein adsorption material surface.

4. The low protein adsorption material according to claim 3 , wherein the polymerization initiator is at least one of a benzophenone compound and a thioxanthone compound.

5. The low protein adsorption material according to claim 3 , wherein the adsorbed polymerization initiator is further chemically bonded to the low protein adsorption material surface by light irradiation.

6. The low protein adsorption material according to claim 2 , wherein the radical polymerization is photo-radical polymerization.

7. The low protein adsorption material according to claim 6 , wherein the photo-radical polymerization comprises irradiation with light having a wavelength of 300 to 450 nm.

8. The low protein adsorption material according to claim 2 , wherein the radical polymerization comprises introduction of an inert gas into a reaction container containing the low protein adsorption material and exposure of the low protein adsorption material to light irradiation along with introduction of a reaction solution into the reaction container during or before light irradiation, so as to polymerize the monomer in an atmosphere of the inert gas.

9. The low protein adsorption material according to claim 2 , wherein the monomer containing a C—N bond in a molecule thereof is at least one selected from the group consisting of (meth)acrylamide, dimethyl(meth)acrylamide, diethyl(meth)acrylamide, isopropyl(meth)acrylamide, hydroxy(meth)acrylamide, and (meth)acryloyl morpholine.

10. The low protein adsorption material according to claim 6 , wherein the photo-radical polymerization comprises contacting the monomer containing a C—N bond in a molecule thereof or a solution of the monomer with the low protein adsorption material surface to which a polymerization initiator is adsorbed or covalently bonded, and then irradiating the low protein adsorption material surface with light to polymerize the monomer.

11. The low protein adsorption material according to claim 10 , wherein the monomer containing a C—N bond in a molecule thereof or the solution of the monomer includes a polymerization inhibitor, and the monomer is polymerized in the presence of the polymerization inhibitor.

12. The low protein adsorption material according to claim 11 , wherein the polymerization inhibitor is 4-methylphenol.

13. The low protein adsorption material according to claim 2 , wherein the polymer chains each have a length of 10 to 50,000 nm.

Assignees

• Sumitomo Rubber Ind

Inventors

• Minagawa Yasuhisa

Classifications

• C08J2323/28

  by reaction with halogens or halogen-containing compounds (C08J2323/32 takes precedence) · CPC title

• A61L29/06

  obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds · CPC title

• A61M5/31513

  Piston constructions to improve sealing or sliding · CPC title

• C08J2433/26

  Homopolymers or copolymers of acrylamide or methacrylamide · CPC title

• C08F291/02

  on to elastomers · CPC title