Substrates for imaging glucocerebrosidase activity
US-2025130225-A1 · Apr 24, 2025 · US
US9751906B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9751906-B2 |
| Application number | US-201314409604-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jun 20, 2013 |
| Priority date | Jun 20, 2012 |
| Publication date | Sep 5, 2017 |
| Grant date | Sep 5, 2017 |
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The invention relates to the field of carbohydrate chemistry. Provided is a process for the regioselective oxidation of a single secondary hydroxy function of a carbohydrate substrate comprising two or more secondary hydroxy functions, comprising contacting the carbohydrate substrate in a solvent in the presence of a transition metal catalyst complex with an oxidizing agent to yield a mono-oxidized carbohydrate.
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The invention claimed is: 1. A process for the regioselective oxidation of a single secondary hydroxy function of a carbohydrate substrate comprising two or more secondary hydroxy functions, wherein the carbohydrate substrate is a neamine-based aminoglycoside antibiotic selected from the group consisting of neomycin, neamin, amikacin, paromomycin, ribostamycin, kanamycin, framycetin, isepamicin, and derivatives thereof, and wherein the single secondary hydroxyl function is the C3 h…
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
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