Nitrogen-containing heterocyclic compound or salt thereof
US-2015322063-A1 · Nov 12, 2015 · US
US9751854B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9751854-B2 |
| Application number | US-201615347334-A |
| Country | US |
| Kind code | B2 |
| Filing date | Nov 9, 2016 |
| Priority date | Jan 14, 2014 |
| Publication date | Sep 5, 2017 |
| Grant date | Sep 5, 2017 |
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The present invention provides a compound of formula I: and pharmaceutically acceptable salts thereof, wherein X, R 1 , R 2 , R 3 , R 4 , R 5 , L 1 , L 2 , m, and n, are as described in the specification. Such compounds are inhibitors of VPS34 and thus useful for treating proliferative, inflammatory, or cardiovascular disorders.
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We claim: 1. A compound selected from the group consisting of: or a pharmaceutically acceptable salt thereof. 2. The compound of claim 1 , which is or a pharmaceutically acceptable salt thereof. 3. The compound of claim 1 , which is or a pharmaceutically acceptable salt thereof. 4. The compound of claim 1 , which is or a pharmaceutically acceptable salt thereof. 5. A pharmaceutical composition comprising the compound of claim 1 or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier. 6. The pharmaceutical composition of claim 5 , wherein the compound is or a pharmaceutically acceptable salt thereof. 7. The pharmaceutical composition of claim 5 , wherein the compound is or a pharmaceutically acceptable salt thereof. 8. The pharmaceutical composition of claim 5 , wherein the compound is or a pharmaceutically acceptable salt thereof.
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