Antimicrobial biguanide metal complexes

Patent metadata

Field	Value
Publication number	US-9751833-B2
Application number	US-92289406-A
Country	US
Kind code	B2
Filing date	Jun 27, 2006
Priority date	Jun 27, 2005
Publication date	Sep 5, 2017
Grant date	Sep 5, 2017

Abstract

A compound comprising a metal species and a biologically acceptable ligand, wherein the biologically acceptable ligand comprises a biguanide moiety, and wherein the biologically acceptable ligand forms a complex with the metal species in which the metal species is stabilised in an oxidation state greater than 1+. Compositions and medical devices comprising the compound. A method for the treatment or prophylaxis of microbial, including bacterial, infections, comprising the use of such compounds, compositions or medical devices.

First claim

The invention claimed is:

1. A method for the treatment of microbial infections, comprising administering to an individual a compound comprising a metal species and a biologically acceptable ligand, wherein the metal species is selected from the group consisting of silver (III), copper (III), and gold (III); wherein the biologically acceptable ligand comprises a biguanide moiety; wherein the biologically acceptable ligand forms a complex with the metal species in which the metal species is stabilized in an oxidation state greater than 1+; and wherein the step of administering to an individual comprises contacting the individual with the compound.

2. The method of claim 1 , wherein contacting the individual with the compound comprises contacting the individual with a medical device comprising the compound.

3. The method of claim 1 , wherein the biologically acceptable ligand has the formula:

wherein R 1 , R 2 , and R 3 are independently H or a hydrocarbyl group.

4. The method of claim 1 , wherein the biologically acceptable ligand has the formula:

wherein R 1 , R 2 , R 3 , and R 4 are independently H or a hydrocarbyl group and R 5 is a hydrocarbadiyl group.

5. The method of claim 1 , wherein the biologically acceptable ligand has the formula:

wherein R is a hydrocarbadiyl group and n is 1 or more.

6. The method of claim 1 , wherein the biologically acceptable ligand is selected from the group consisting of poly(hexamethylenebiguanide), chlorhexidine (1,1′-hexamethylenebis[5-(p-chlorophenyl)biguanide], metformin (N′, N′dimethylbiguanide), phenformin (phenethylbiguanide) and buformin (N-butylbiguanide).

7. The method of claim 2 , wherein the medical device comprises a wound or burn dressing, an implant, a scaffold for tissue repair, or a stent.

Assignees

• Greener Bryan
• Smith & Nephew

Inventors

• Greener Bryan

Classifications

• A61P31/00

  Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics · CPC title

• C07C279/26

  X and Y being nitrogen atoms, i.e. biguanides · CPC title

• A61P31/04

  Antibacterial agents · CPC title

• A01N59/16

  Heavy metals; Compounds thereof · CPC title

• C07C279/265 Primary

  containing two or more biguanide groups · CPC title