Drug eluting medical devices

Patent metadata

Field	Value
Publication number	US-9750839-B2
Application number	US-201213429482-A
Country	US
Kind code	B2
Filing date	Mar 26, 2012
Priority date	Jun 30, 2011
Publication date	Sep 5, 2017
Grant date	Sep 5, 2017

Abstract

Medical devices possessing coatings are provided. The coatings include at least one polyelectrolyte, capable of changing the surface charge of the device to which they are applied. The polyelectrolytes permit attachment of charged bioactive agents thereto. Multiple polyelectrolytes, possessing opposite charges, may be sequentially applied to produce a medical device having multiple layers. Methods for forming such devices are also provided.

First claim

What is claimed is:

1. A medical device comprising:
a substrate possessing a charge;
at least a first layer comprising a polymer comprising a first polyelectrolyte in combination with at least one bioactive agent, the first polyelectrolyte possessing a charge opposite the charge on the substrate; and
at least a second layer comprising a polymer comprising a second polyelectrolyte in combination with at least one bioactive agent, the second polyelectrolyte possessing a charge opposite the charge on the first polyelectrolyte,
wherein an outer layer of the medical device comprises the first layer or second layer, and the outer layer further comprises a polymer capable of releasing its bioactive agent over a period of from about 1 second to about 6 months, with an inner layer comprising the other of the first layer or second layer under the outer layer, the inner layer formed of a polymer which releases its bioactive agent over a period of from about 30 minutes to about 2 weeks.

2. The medical device according to claim 1 , wherein the at least one layer comprising a first polyelectrolyte is disposed on the substrate.

3. The medical device according to claim 1 , wherein the at least one layer comprising a second polyelectrolyte is disposed on the at least one layer comprising the first polyelectrolyte.

4. The medical device according to claim 1 , wherein the substrate is selected from the group consisting of meshes, buttresses, tapes, felts, scaffolds, patches, pledgets, tissue reinforcements, sutures, tacks, and staples.

5. The medical device according to claim 1 , wherein the substrate comprises a material selected from the group consisting of collagen, gelatin, polypropylene and polyester.

6. The medical device according to claim 1 , wherein the substrate possesses a positive charge, the first polyelectrolyte comprises a polyanion, and the second polyelectrolyte comprises a polycation.

7. The medical device according to claim 1 , wherein the substrate possesses a negative charge, the first polyelectrolyte comprises a polycation, and the second polyelectrolyte comprises a polyanion.

8. The medical device according to claim 1 , further comprising a charged species selected from the group consisting of nanoparticles, clay platelets, glass beads, metal alloys, and combinations thereof.

9. The medical device according to claim 1 , wherein the medical device possesses from about 2 to about 30 layers comprising the first polyelectrolyte, and from 2 about 30 layers comprising the second polyelectrolyte.

10. The medical device according to claim 9 , wherein the layers comprising the first polyelectrolyte and the layers comprising the second polyelectrolyte are in an alternating configuration.

11. The medical device according to claim 1 , wherein the medical device possesses a positive charge, and the bioactive agent possesses a negative charge.

12. The medical device according to claim 11 , wherein the bioactive agent is selected from the group consisting of DNA, proteins, growth factors, and combinations thereof.

13. The medical device according to claim 1 , wherein the medical device possesses a negative charge, and the bioactive agent possesses a positive charge.

14. The medical device according to claim 13 , wherein the bioactive agent is selected from the group consisting of growth factors, drugs, and combinations thereof.

15. A surgical buttress comprising the medical device of claim 1 .

16. A hernia mesh comprising the medical device of claim 1 .

17. A medical device comprising:
a substrate possessing a charge;
at least a first layer comprising clay platelets in combination with at least one bioactive agent, the clay platelets possessing a charge opposite the charge on the substrate;
at least a second layer comprising a polymer comprising a polyelectrolyte in combination with at least one bioactive agent, the polyelectrolyte possessing a charge opposite the charge on the clay platelets,
wherein an outer layer of the medical device comprising the first layer or second layer releases its bioactive agent over a period of from about 1 second to about 6 months, with a layer comprising the other of the first layer or second layer under the outer layer releasing its bioactive agent over a period of from about 30 minutes to about 2 weeks.

18. A medical device comprising:
a substrate possessing a charge;
at least a first layer comprising a polymer comprising a polyelectrolyte in combination with at least one bioactive agent, the polyelectrolyte possessing a charge opposite the charge on the substrate;
at least a second layer comprising clay platelets in combination with at least one bioactive agent, the clay platelets possessing a charge opposite the charge on the polyelectrolyte,
wherein an outer layer of the medical device comprising the first layer or the second layer releases its bioactive agent over a period of from about 1 second to about 6 months, with a layer under the outer layer comprising the other of the first layer or the second layer releasing its bioactive agent over a period of from about 30 minutes to about 2 weeks.

Assignees

• Desai Arpan
• Covidien Lp

Inventors

• Desai Arpan

Classifications

• A61L31/16

  Biologically active materials, e.g. therapeutic substances {(A61L31/047 takes precedence)} · CPC title

• A61L2300/258

  Genetic materials, DNA, RNA, genes, vectors, e.g. plasmids · CPC title

• A61L17/145 Primary

  Coating · CPC title

• A61L2420/08

  Coatings comprising two or more layers · CPC title

• A61L17/005

  containing a biologically active substance, e.g. a medicament or a biocide · CPC title