Compositions for use as a prophylactic agent to those at risk of infection of tuberculosis, or as secondary agents for treating infected tuberculosis patients
US-2024382575-A1 · Nov 21, 2024 · US
Compositions and methods
US9750794B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9750794-B2 |
| Application number | US-201615067469-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 11, 2016 |
| Priority date | Jul 25, 2008 |
| Publication date | Sep 5, 2017 |
| Grant date | Sep 5, 2017 |
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- Title
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Abstract
Official abstract text for this publication.
The present invention is directed to a polypeptide which comprises: (i) an Rv1753c protein sequence; (ii) a variant of an Rv1753c protein sequence; or (iii) an immunogenic fragment of an Rv1753c protein sequence. In other aspects the invention is directed to associated polynucleotides, fusion proteins and methods for the treatment or prevention of tuberculosis.
First claim
Opening claim text (preview).
We claim: 1. A pharmaceutical composition comprising: (a) a polynucleotide encoding an Rv1753c polypeptide comprising an amino acid sequence at least 70% identical to the amino acid sequence of SEQ ID No: 1; and (b) a pharmaceutically acceptable carrier or excipient. 2. The pharmaceutical composition according to claim 1 , wherein the polynucleotide further comprises a heterologous nucleic acid sequence. 3. The pharmaceutical composition according to claim 2 , wherein the polynucleotide further comprising a heterologous nucleic acid sequence encodes a fusion polypeptide. 4. The pharmaceutical composition according to claim 2 , wherein the polynucleotide further comprises a vector. 5. An immunogenic composition comprising: (a) a polynucleotide encoding an Rv1753c polypeptide comprising an amino acid sequence at least 70% identical to the amino acid sequence of SEQ ID NO:1; and (b) an immunostimulant. 6. The immunogenic composition according to claim 5 , wherein the polynucleotide further comprises a heterologous nucleic acid sequence. 7. The immunogenic composition according to claim 6 , wherein the polynucleotide further comprising a heterologous nucleic acid sequence encodes a fusion polypeptide. 8. The immunogenic composition according to claim 6 , wherein the polynucleotide further comprises a vector.
Assignees
Inventors
Classifications
Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title
for tuberculosis · CPC title
Immunostimulants · CPC title
from bacteria · CPC title
with deoxyribosyl as saccharide radical · CPC title
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Frequently asked questions
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- What does patent US9750794B2 cover?
- The present invention is directed to a polypeptide which comprises: (i) an Rv1753c protein sequence; (ii) a variant of an Rv1753c protein sequence; or (iii) an immunogenic fragment of an Rv1753c protein sequence. In other aspects the invention is directed to associated polynucleotides, fusion proteins and methods for the treatment or prevention of tuberculosis.
- Who is the assignee on this patent?
- Glaxosmithkline Biologicals Sa, Glaxosmithkline Biologicals Sa, Glaxo Group Ltd
- What technology area does this patent fall under?
- Primary CPC classification A61K39/04. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Sep 05 2017 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).