Aqueous polyglycidol synthesis with ultra-low branching

Patent metadata

Field	Value
Publication number	US-9745419-B2
Application number	US-201514605602-A
Country	US
Kind code	B2
Filing date	Jan 26, 2015
Priority date	Jan 24, 2014
Publication date	Aug 29, 2017
Grant date	Aug 29, 2017

Abstract

Disclosed herein are glycidol-based polymers, nanoparticles, and methods related thereto useful for a variety of applications, including, but not limited to, drug delivery. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

First claim

What is claimed is:

1. A method for making a polymer, the method comprising the step of polymerizing glycidol in an aqueous solution, wherein the method makes a polymer that comprises repeating units selected from:

wherein R 0 is selected from H, alkyl, NH 2 , and R 1 ;
wherein R 1 comprises a crosslinking functionality;
wherein repeating units A1 and A2 account for at least about 50 wgt % of the polymer; and
wherein repeating units selected from:

are substantially absent from the polymer.

2. The method of claim 1 , wherein the aqueous solution is a buffer.

3. The method of claim 1 , wherein the aqueous solution does not comprise a metal catalyst.

4. The method of claim 1 , wherein the aqueous solution has a pH from about 3.0 to about 9.0.

5. The method of claim 1 , wherein the polymerization is initiated from a macromolecular structure.

6. The method of claim 1 , wherein the polymerization step is performed at a temperature from about 50° C. to about 120° C.

7. The method of claim 1 , wherein the polymer does not comprise a

moiety.

8. The method of claim 1 , wherein the polymer further comprises at least one repeating unit formed from a monomer selected from:

or a combination thereof.

9. A method for making a polymer, the method comprising the step of polymerizing glycidol in an aqueous solution, wherein the method makes a polymer that comprises repeating units selected from:

wherein R 0 is selected from H, alkyl, NH 2 , and R 1 ;
wherein R 1 comprises a crosslinking functionality;
wherein repeating units A1, A2, B1, and B2 account for at least about 50 wgt % of the polymer; and
wherein the ratio of (A1+A2):(B1+B2) is greater than 1,
wherein the aqueous solution does not comprise a metal catalyst.

10. The method of claim 9 , wherein the polymerization is initiated from a macromolecular structure.

11. The method of claim 9 , wherein the polymerization step is performed at a temperature from about 50° C. to about 120° C.

12. The method of claim 9 , wherein the polymer does not comprise a

moiety.

13. The method of claim 9 , wherein the polymer further comprises at least one repeating unit formed from a monomer selected from:

or a combination thereof.

Assignees

• Univ Vanderbilt

Inventors

• Harth Eva M
• Spears Benjamin R

Classifications

• C08G2650/38

  containing oxygen in addition to the ether group · CPC title

• C08G2650/56

  Polyhydroxyethers, e.g. phenoxy resins · CPC title

• C08G2650/24

  Polymeric initiators · CPC title

• C08G65/34 Primary

  from hydroxy compounds or their metallic derivatives {(C08G65/26 takes precedence)} · CPC title

• C08G65/22 Primary

  Cyclic ethers having at least one atom other than carbon and hydrogen outside the ring · CPC title