Therapeutic bisphosphonates

Patent metadata

Field	Value
Publication number	US-9745331-B2
Application number	US-201314412578-A
Country	US
Kind code	B2
Filing date	Jul 3, 2013
Priority date	Jul 5, 2012
Publication date	Aug 29, 2017
Grant date	Aug 29, 2017

Abstract

The invention provides novel pyrophosphate synthase inhibitors of formula I and formula II as well salts thereof; the invention also provides compositions comprising such inhibitors and methods for their use.

First claim

What is claimed is:

1. A compound of formula I:

wherein:
X is —(CH 2 ) m — or —(CH 2 ) m CH(CH 3 )—
m is an integer from 1 to 2;
R 1 is a saturated or unsaturated (C 1 -C 20 )alkyl chain;
R 2 is H or methyl;
each R 3 , R 4 , R 5 , and R 6 is independently OH, or (C 1 -C 6 )alkoxy;
R 7 is

or a salt thereof.

2. A pharmaceutical composition comprising a compound as described in claim 1 and a pharmaceutically acceptable carrier.

3. The compound of claim 1 which is:

or a salt thereof.

4. A pharmaceutical composition comprising a compound as described in claim 3 and a pharmaceutically acceptable carrier.

Assignees

• Univ Iowa Res Found

Inventors

• Wiemer David

Classifications

• A61P3/10

  for hyperglycaemia, e.g. antidiabetics · CPC title

• A61P9/00

  Drugs for disorders of the cardiovascular system · CPC title

• A61P9/06

  Antiarrhythmics · CPC title

• A61P35/00

  Antineoplastic agents · CPC title

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title