Metal free process for allylic oxidation

Patent metadata

Field	Value
Publication number	US-9745240-B2
Application number	US-201414908965-A
Country	US
Kind code	B2
Filing date	Jul 28, 2014
Priority date	Jul 29, 2013
Publication date	Aug 29, 2017
Grant date	Aug 29, 2017

Abstract

The patent discloses a novel metal free process for the preparation of corresponding phenol and ketone via allylic oxidation of substituted cyclohexenes. Air is used as oxidant in the present process and can be used as such or optionally selected from pure oxygen or atmospheric oxygen. Moreover, the process of the present invention utilizes easily available starting materials and is a green eco-friendly, convenient and economical process with high yield of >60% and high selectivity.

First claim

The invention claimed is:

1. A metal free process for the synthesis of a phenol compound of Formula I or a ketone compound of Formula II,

wherein, R is selected from CHO, COR 3 , COOR 4 , COOH, CN, NO 2 , Ts, nitroethene, α,β unsaturated ketone, or α,β-unsaturated ester;
R 1 is selected from halides, phenyl or p-F-Ph;
R 2 is selected from H or alkyl;
R 3 is selected from alkyl, allyl or phenyl;
R 4 is selected from alkyl, allyl or benzyl;
the process comprising:
a. mixing a substituted cyclohexene of formula III

wherein, R, R 1 , R 2 , R 3 and R 4 are as above and a solvent, with continuous bubbling of molecular oxygen at 50 to 100° C. for 5 to 60 hours;
b. extracting the product of step (a); and
c. purifying the product of step (b) to obtain the phenol compound of Formula I or ketone compound of Formula II which is substantially purified.

2. The process according to claim 1 , wherein the extraction step involves filtering the product of step (a); treating the filtrate with water; extracting with a solvent; washing the organic extract with brine; drying the organic extract with anhydrous Na 2 SO 4 ; filtering the organic extract and removing the solvent in vacuo.

3. The process according to claim 1 , wherein the purification is done by column chromatography.

4. The process according to claim 1 , wherein the solvent is selected from water, methanol, isopropyl alcohol, methyl cyanide, dimethyl formamide or degassed dimethyl formamide, either alone or in combination with tetrahydrofuran.

5. The process according to claim 1 , wherein the step (a) mixing a substituted cyclohexene of formula III and a solvent further comprises a base selected from alkali carbonates including Potassium carbonate and Cesium carbonate, 1,4-diazabicyclo[2.2.2]octane, 4-dimethylaminopyridine, 2,6-lutidine, triphenylphosphine, imidazole, triethylamine or pyridine.

6. The process according to claim 1 , wherein the molecular oxygen is selected from pure oxygen or atmospheric oxygen.

7. The process according to claim 1 , wherein the yield of phenol compound of Formula I or ketone compound of Formula II is greater than 60%.

8. The process according to claim 1 , wherein the temperature is in the range of 70 to 90° C.; time is in the range of 20 to 40 hours and yield is greater than 75%.

9. The process according to claim 1 , wherein the compound of Formula I is selected from the group consisting of 3-hydroxybenzaldehyde; 3-Hydroxy-5-methylbenzaldehyde; 3-(tert-Butyl)-5-hydroxybenzaldehyde; 6-Hydroxy-[1,1′-biphenyl]-2-carbaldehyde; 4′-Fluoro-6-hydroxy-[1,1′-biphenyl]-2-carbaldehyde; (E)-4-(3-Hydroxyphenyl)but-3-en-2-one; (E)-3-(3-Hydroxyphenyl)-1-phenylprop-2-en-1-one; (E)-3-(3-Hydroxyphenyl)-1-(p-tolyl)prop-2-en-1-one; (E)-3-(3-Hydroxyphenyl)-1-(4-methoxyphenyl)prop-2-en-1-one; (E)-Ethyl 3-(3-hydroxyphenyl)acrylate; (E)-Ethyl 3-(3-hydroxy-5-methylphenyl)acrylate; and (E)-Ethyl 3-(3-(tert-butyl)-5-hydroxyphenyl)acrylate.

10. The process according to claim 1 , wherein the compound of Formula II is selected from the group consisting of 2-Chloro-3-oxocyclohex-1-enecarbaldehyde; and 6-Oxo-3,4,5,6-tetrahydro-[1,1′-biphenyl]-2-carbaldehyde.

11. The process according to claim 1 , wherein R 2 is methyl, tertiary butyl or phenyl.

12. The process according to claim 2 , wherein the extracting solvent is EtOAc.

13. The process according to claim 3 , wherein the column chromatography is flash column chromatography.

14. The process according to claim 4 , wherein the yield of phenol compound of Formula I or ketone compound of Formula II is greater than 60%.

15. The process according to claim 6 , wherein the molecular oxygen is atmospheric oxygen.

Assignees

• Council Scient Ind Res

Inventors

• Chavan Subhash Prataprao
• Lasonkar Pradeep Bhaskarrao

Classifications

• C07C45/34 Primary

  in unsaturated compounds · CPC title

• C07C45/64

  by introduction of functional groups containing oxygen only in singly bound form · CPC title

• C07C2601/16

  the ring being unsaturated · CPC title

• C07C47/565

  all hydroxy groups bound to the ring · CPC title

• C07C49/248

  having unsaturation outside the aromatic rings · CPC title