System and method for neural cochlea stimulation

Patent metadata

Field	Value
Publication number	US-9744358-B2
Application number	US-201315024426-A
Country	US
Kind code	B2
Filing date	Sep 30, 2013
Priority date	Sep 30, 2013
Publication date	Aug 29, 2017
Grant date	Aug 29, 2017

Abstract

A system having a device for neural stimulation of a patient's cochlea, an in-situ device for measuring a patient's response to the neural stimulation of the cochlea, and a programming unit for adjusting the stimulation device; the stimulation device having a stimulation signal unit for generating a stimulation signal formed of pulses having a shape determined by a shape parameter set including at least one shape parameter; a cochlear implant stimulation arrangement with a plurality of stimulation channels for stimulating the cochlea based on the stimulation signal; the measuring device providing patient-specific response data concerning the stimulation response to a programming unit that controls the stimulation signal unit by subsequently supplying a plurality of different test shape parameter sets to the stimulation signal unit for causing the stimulation signal unit to generate corresponding test pulses, the programming unit evaluating each test shape parameter set based on stimulation response data.

First claim

What is claimed is:

1. A system comprising a device for neural stimulation of a cochlea of a patient, means for in-situ measuring a stimulation response of the patient to the neural stimulation of the cochlea, and a programming unit for adjusting the stimulation device;
the stimulation device comprising
a stimulation signal unit adapted to generate a stimulation signal for each stimulation channel included in a plurality of stimulation channels, the stimulation signal including pulses having a shape determined by a shape parameter set including at least one shape parameter;
a cochlear implant stimulation arrangement comprising the plurality of stimulation channels and configured to stimulate the cochlea according to the stimulation signal;

the measuring means being adapted to provide, to the programming unit, patient-specific response data concerning the stimulation response,
the programming unit being adapted to control the stimulation signal unit by
subsequently supplying a plurality of different test shape parameter sets to the stimulation signal unit and thereby causing the stimulation signal unit to generate a plurality of test pulses that each correspond to a different test shape parameter set included in the plurality of test shape parameter sets,
evaluating each test shape parameter set included in the plurality of test shape parameter sets according to the respective stimulation response data supplied by the measuring means and according to a power consumption of the plurality of test pulses generated according to the respective test shape parameter sets,
determining an optimal test shape parameter set included in the plurality of test shape parameter sets and that has a lowest power consumption per test pulse for a given stimulation response to a test pulse generated according to the optimal test shape parameter set, and

programming the stimulation device based on the optimal test shape parameter set.

2. The system of claim 1 , wherein the cochlear implant stimulation arrangement comprises a plurality of electrodes for electrical stimulation of the cochlea.

3. The system of claim 1 wherein the programming unit is adapted to determine the optimal test shape parameter set for each stimulation channel separately.

4. The system of claim 3 , wherein the programming unit is adapted to cause the stimulation unit to apply test pulses only to one stimulation channel at a time.

5. The system of claim 1 , wherein the programming unit is adapted to stop the search for the optimal test shape parameter set after a given time period has lapsed since the start of the search.

6. The system of claim 1 , wherein the programming unit is adapted to stop the search for the optimal test shape parameter set when for given time period no test shape parameter set has been found having a better evaluation than the already evaluated test shape parameter sets.

7. The system of claim 1 , wherein the programming unit is adapted to obtain for each test shape parameter set an amplitude scaling factor required to evoke a predetermined response by the patient, the programming unit being further adapted to use the amplitude scaling factor for evaluating the power consumption of the respective test pulse.

8. The system of claim 7 , wherein the predetermined response is a threshold level.

9. The system of claim 1 , wherein the programming unit is adapted to provide the test shape parameter sets such that each test shape parameter set results in the same predetermined power consumption of the respective test pulse, the programming unit being further adapted to select that test shape parameter set as the optimal test shape parameter set which results in the largest stimulation response level.

10. The system of claim 1 , wherein the programming unit is adapted to supply and evaluate the test shape parameter sets in subsequent groups, wherein for each group an optimal test shape parameter set is determined, wherein the test shape parameter sets of each group are selected according to the evaluation result of the previous group test shape parameter sets, and wherein that optimal test shape parameter set is selected for programming of the stimulation device which has the best evaluation.

11. The system of claim 1 , wherein the stimulation device comprises means for providing an input audio signal and a sound processor for generating a neural stimulation signal from the input audio signal, with the sound processor comprising the stimulation signal unit.

12. The system of claim 1 , wherein the measuring means is adapted to measure electrically-evoked compound action potentials (ECAPs) and base the patient-specific response data on the measured ECAPs.

13. The system of claim 12 , wherein the measuring means comprises the stimulation electrodes, the measuring means being adapted to transmit the response data via a reverse telemetry link to the sound processor.

14. The system of claim 1 , wherein the measuring means is adapted to measure auditory brain stem responses (ABRs) and base the patient-specific response data on the measured ABRs.

15. The system of claim 1 , wherein the measuring means is adapted to provide the patient-specific response data from electrically evoked stapedius reflex, post-auricular muscle reflex, cortical potentials or iris contraction measurements.

16. The system of claim 1 , wherein the measuring means is adapted to measure electro-encephalography (EEG) responses, magneto-encephalography (MEG) responses, or functional imaging measurements and base the patient-specific response data on the EEG responses, MEG responses, or functional imaging measurements.

17. The system of claim 1 , wherein the measuring means is adapted to perform psychophysical measurements and base the patient-specific response data on the psychophysical measurements.

18. The system of claim 1 , wherein the pulses are staircase pulses, a sum of exponentials pulses or a sum of Gaussians pulses.

19. The system of claim 1 , wherein the stimulation signal unit is for generating biphasic pulses.

20. The system of claim 1 , wherein the programming unit is implemented by a PC communicating with the stimulation device via a programming interface.

21. A method of individually adjusting a device for neural stimulation of a cochlea of a patient, comprising:
generating, by a stimulation signal unit, a test stimulation signal, the test stimulation signal including pulses having a test shape determined by a test shape parameter set including at least one shape parameter;
supplying the stimulation signal to a cochlear implant arrangement comprising a plurality of stimulation channels for stimulating the cochlea according to the test stimulation signal;
obtaining patient-specific response data concerning the stimulation response to the test stimulation signal by in-situ measuring a response of the patient to the stimulation of the cochlea;
repeating the preceding steps with different test shape parameter sets;
evaluating each test shape parameter set according to the respective stimulation response data and according to a power consumption of the pulse generated according to the respective test shape parameter set;
determining an optimal test shape parameter set having a lowest power consumption per pulse for a given stimulation response to a pulse generated according to that test shape parameter set; and
programming the stimulation device based on the optimal test shape parameter set.

22. The method of claim 21 , wherein the

Assignees

• Advanced Bionics Ag

Inventors

• Hehrmann Phillipp
• Akhoun Idrick

Classifications

• A61N1/36039

  fitting procedures · CPC title

• A61N1/0541 Primary

  Cochlear electrodes · CPC title

• A61N1/37241

  providing test stimulations · CPC title

• A61B5/12

  Audiometering · CPC title

• A61B5/4047

  afferent nerves, i.e. nerves that relay impulses to the central nervous system · CPC title