Timing controlled in-situ cross-linking of halyuronic acid during injection

Patent metadata

Field	Value
Publication number	US-9744260-B2
Application number	US-201314255956-A
Country	US
Kind code	B2
Filing date	Apr 12, 2013
Priority date	Apr 12, 2013
Publication date	Aug 29, 2017
Grant date	Aug 29, 2017

Abstract

Systems and methods are disclosed for cosmetic augmentation by forming a biocompatible cross-linked polymer having a multi-phase mixture with a time release catalyst; injecting the mixture into a patient as a viscous fluid; after injection, activating the catalyst to cross-link the polymer after a predetermined period after injection into a patient; and augmenting soft tissue with the biocompatible cross-linked polymer.

First claim

What is claimed is:

1. A method for cosmetic augmentation, comprising:
modeling a 3D model of a human body and continuously updating a current shape of breast or butt from the 3D model to fit to a desired shape;
forming a biocompatible cross-linked polymer having a multi-phase mixture with a time activated catalyst;
injecting the mixture into a patient as a homogeneous fluid;
after injection, activating the catalyst to cross-link the polymer after a predetermined period after injection into a patient; and
augmenting soft tissue with the biocompatible cross-linked polymer.

2. The method of claim 1 , comprising providing a predetermined controlled release of selected pharmaceutical substance to modulate soft tissue response to the polymer.

3. The method of claim 1 , comprising cross-linking the polymer in a shell inside the patient.

4. The method of claim 1 , wherein the polymer comprises one of: collagens, hyaluronic acids, celluloses, proteins, saccharides.

5. The method of claim 1 , wherein the polymer comprises an extracellular matrix of a biological system.

6. The method of claim 1 , comprising using cross linkers and forming homo-polymers or to form copolymers by crosslinking with other polymer species.

7. The method of claim 1 , comprising adding a substance to the composition for biocompatibility.

8. The method of claim 1 , comprising controlling drug releases at predetermined timing in anticipation of an onset of a negative physiological event in response to invading foreign bodies.

9. The method of claim 1 , comprising fast releasing the composition.

10. The method of claim 1 , comprising adding anesthetics, lidocaine or compound to reduce or eliminate acute inflammatory reactions to the pharmaceutical substance.

11. The method of claim 1 , comprising adding one or more compositions selected from the group consisting of steroids, corticosteroids, dexamethasone, triamcinolone.

12. The method of claim 1 , comprising providing a slow release substance to the pharmaceutical substance.

13. The method of claim 1 , comprising providing an antiproliferative compound.

14. The method of claim 1 , wherein the substance comprises paclitaxel, serolimas.

15. The method of claim 1 , comprising controlling the scar formation process around a foreign body including capsular formation.

16. The method of claim 1 , comprising providing a medium release to the pharmaceutical substance.

17. The method of claim 1 , comprising optimizing degradation profile of the composition.

18. The method of claim 1 , comprising minimizing migration of the composition.

19. The method of claim 1 , comprising controlling an average molecular weight (Mn) and the polydispersity index.

20. The method of claim 1 , comprising characterizing a target tissue, and maintaining a consistency of the composition in particle size and population densities.

21. The method of claim 1 , comprising co-cross-linking glycosaminoglycan chemically with at least one other polymer including hyaluronan or hylan.

22. The method of claim 1 , comprising adding a biodegradable surfactant or plasticizer to reduce surface tension of material as it is injected into a patient through a small diameter needle.

23. The method of claim 1 , comprising injecting with a mechanical pump the biocompatible crosslinked polymer under soft tissue in a minimally invasive manner.

24. A method for cosmetic augmentation, comprising:
modeling a 3D model of a human body and continuously updating a current shape of breast or butt from the 3D model to fit to a desired shape,
forming a biocompatible cross-linked polymer having a multi-phase mixture with a predetermined controlled release of selected pharmaceutical substance to modulate soft tissue response to the polymer;
injecting the mixture into a patient and during or after injection, cross-linking the polymer in the patient;
filling a semi-permeable shell with the pharmaceutical substance; and
augmenting soft tissue with the biocompatible cross-linked polymer.

Assignees

• Nguyen Phi
• Phan Loc
• Tran Bao
• Nguyen Thuan
• Bui Duy

Inventors

• Nguyen Phi
• Phan Loc
• Tran Bao
• Nguyen Thuan
• Bui Duy

Classifications

• A61L27/58

  Materials at least partially resorbable by the body · CPC title

• A61L2300/222

  Steroids, e.g. corticosteroids · CPC title

• A61L27/20 Primary

  Polysaccharides · CPC title

• A61L27/16 Primary

  obtained by reactions only involving carbon-to-carbon unsaturated bonds · CPC title

• A61L2300/416

  Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus · CPC title