Controlled release active agent carrier

Patent metadata

Field	Value
Publication number	US-9744107-B2
Application number	US-99806009-A
Country	US
Kind code	B2
Filing date	Sep 29, 2009
Priority date	Sep 30, 2008
Publication date	Aug 29, 2017
Grant date	Aug 29, 2017

Abstract

The present invention relates to carriers for the controlled release of active agents, comprising surface reacted natural or synthetic calcium carbonate, one or more active agents, wherein said one or more active agent is associated with said surface-reacted calcium carbonate, and wherein said surface-reacted natural or synthetic calcium carbonate is a reaction product of natural or synthetic calcium carbonate with carbon dioxide and one or more acids, wherein the carbon dioxide is formed in situ by the acid treatment and/or is supplied from an external source. It further relates to the preparation of loaded carriers, as well as their use in different applications.

First claim

The invention claimed is:

1. A cosmetic formulation comprising an admixture of:
(a) a surface reacted natural calcium carbonate in powder or granule form that is a reaction product of natural calcium carbonate with carbon dioxide and one or more acids in an aqueous environment, wherein the carbon dioxide is formed in situ by the acid treatment and/or is supplied from an external source, and wherein the natural calcium carbonate is marble, calcite, chalk, limestone, or any mixture thereof,
(b) one or more active agents adsorbed onto and/or absorbed into the surface-reacted calcium carbonate, and
(c) one or more cosmetically acceptable carriers,
wherein the cosmetic formulation is in the form of a powder, a cream, an emulsion, a gel, a paste, a soap, a gum, or a tablet.

2. The cosmetic formulation according to claim 1 , wherein the one or more acids is selected from the group consisting of hydrochloric acid, sulphuric acid, sulphurous acid, hydrosulphate, phosphoric acid, or oxalic acid, and any mixture thereof.

3. The cosmetic formulation according to claim 1 , wherein the one or more acids is phosphoric acid.

4. The cosmetic formulation according to claim 1 , wherein the surface-reacted calcium carbonate has a specific surface area of from 5 m 2 /g to 200 m 2 /g, measured using nitrogen and the BET method according to ISO 9277.

5. The cosmetic formulation according to claim 1 , wherein the surface-reacted calcium carbonate has a specific surface area of from 20 m 2 /g to 80 m 2 /g, measured using nitrogen and the BET method according to ISO 9277.

6. The cosmetic formulation according to claim 1 , wherein the surface-reacted calcium carbonate has a specific surface area of from 30 m 2 /g to 60 m 2 /g, measured using nitrogen and the BET method according to ISO 9277.

7. The cosmetic formulation according to claim 1 , wherein the surface-reacted calcium carbonate has a weight median grain diameter d 50 of from 0.1 to 50 μm, measured according to the sedimentation method.

8. The cosmetic formulation according to claim 1 , wherein the surface-reacted calcium carbonate has a weight median grain diameter d 50 of from 0.5 to 25 μm, measured according to the sedimentation method.

9. The cosmetic formulation according to claim 1 , wherein the surface-reacted calcium carbonate has a weight median grain diameter d 50 of from 0.8 to 20 μm, measured according to the sedimentation method.

10. The cosmetic formulation according to claim 1 , wherein the surface-reacted calcium carbonate has an intra-particle porosity determined as a pore volume per unit particle volume from 20 vol.-% to 99 vol.-%, calculated from a mercury porosimetry measurement.

11. The cosmetic formulation according to claim 1 , wherein the surface-reacted calcium carbonate has an intra-particle porosity determined as a pore volume per unit particle volume from 30 vol.-% to 70 vol.-%, calculated from a mercury porosimetry measurement.

12. The cosmetic formulation according to claim 1 , wherein the surface-reacted calcium carbonate has an intra-particle porosity determined as a pore volume per unit particle volume from 40 vol.-% to 60 vol.-%, calculated from a mercury porosimetry measurement.

13. The cosmetic formulation according to claim 1 , wherein the one or more active agents is selected from the group consisting of a pharmaceutical active agent, a biological active agent, a scented agent, a flavoring agent, a biocide, a disinfecting agent, a surfactant, a defoamer, a softener, a mineral oil, a wetting agent, a wax, a hydrolytic agent and an anti-dusting oil.

14. The cosmetic formulation according to claim 1 , wherein the one or more active agents is selected from the group consisting of triclosan, limonene, peppermint, silicon, paraffin, o-phenylphenol and Bronopol.

15. The cosmetic formulation according to claim 1 , which is a lipstick, a foundation, a deodorant, a sunscreen, a skin care formulation, a hair care product, a soap, a skin cream, a tooth paste, a bath additive, a foot powder, a facial powder, a sun screen, or a chewing gum.

16. A pharmaceutical formulation comprising an admixture of:
(a) a surface reacted natural calcium carbonate in powder or granule form that is a reaction product of natural calcium carbonate with carbon dioxide and one or more acids in an aqueous environment, wherein the carbon dioxide is formed in situ by the acid treatment and/or is supplied from an external source, and wherein the natural calcium carbonate is marble, calcite, chalk, limestone, or any mixture thereof,
(b) one or more active agents adsorbed onto and/or absorbed into the surface-reacted calcium carbonate, and
(c) one or more pharmaceutically acceptable carriers,
wherein the pharmaceutical formulation is in the form of a capsule, a tablet, a patch, or a cream.

17. An agricultural formulation comprising an admixture of:
(a) a surface reacted natural calcium carbonate in powder or granule form that is a reaction product of natural calcium carbonate with carbon dioxide and one or more acids in an aqueous environment, wherein the carbon dioxide is formed in situ by the acid treatment and/or is supplied from an external source, and wherein the natural calcium carbonate is marble, calcite, chalk, limestone, or any mixture thereof, and
(b) one or more active agents adsorbed onto and/or absorbed into the surface-reacted calcium carbonate,
wherein the one or more active agents is selected from the group consisting of an agricultural agent, a biocide, a pesticide, or a herbicide.

Assignees

• Gane Patrick A C
• Schölkopf Joachim
• Omya Int Ag

Inventors

• Gane Patrick A C
• Schölkopf Joachim

Classifications

• A61K47/12

  Carboxylic acids; Salts or anhydrides thereof · CPC title

• A61Q19/00

  Preparations for care of the skin · CPC title

• A61Q11/00

  Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses · CPC title

• A61K2800/56

  Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms · CPC title

• A61K8/11

  Encapsulated compositions · CPC title