Methods and systems for in-and out-of-die monitoring and characterization of multi-component tablets and for detecting and monitoring stiction and tooling material modifications on punch and die surfaces

Patent metadata

Field	Value
Publication number	US-9739753-B2
Application number	US-201414149356-A
Country	US
Kind code	B2
Filing date	Jan 7, 2014
Priority date	Mar 20, 2006
Publication date	Aug 22, 2017
Grant date	Aug 22, 2017

Abstract

The present invention relates to a methods and systems for monitoring and/or characterizing multi-component tablets and for monitoring punch and die surfaces and, more particularly, to methods and systems for in-die and out-of-die monitoring and/or characterizing multi-component tablets based on acoustic and vibrational spectroscopy and for detecting and monitoring stiction and tooling material modifications on punch and die surfaces during compaction based on acoustic/ultrasonic waves.

First claim

What is claimed is:

1. A method of monitoring or characterizing a multi-component drug tablet during compaction comprising the steps of:
transmitting, by a first transducer, a first set of acoustic waves into a multi-component drug tablet while the multi-component drug tablet is being formed in a die during compaction;
receiving, by a digitizing oscilloscope, a second set of acoustic waves from said multi-component drug tablet while the multi-component drug tablet is being formed in the die during compaction;
analyzing, by the digitizing oscilloscope, data received from said second set of acoustic waves;
calculating, by a processor, a resonance frequency and mode shape of said multi-component drug tablet based on said analyzed data; and
determining, by the processor, a quality level or a defect state of said multi-component drug tablet based on said calculated resonance frequency and mode shape of said multi-component drug tablet.

2. The method of claim 1 , further comprising the step of obtaining an original resonance frequency and mode shape of said multi-component drug tablet.

3. The method of claim 2 , wherein said step of determining further comprises the step of comparing said calculated resonance frequency and mode shape of said multi-component drug tablet with said original resonance frequency and mode shape of said multi-component drug tablet.

4. The method of claim 3 , further comprising the step of presenting said quality level or a defect state of said multi-component drug tablet on a display device.

5. The method of claim 3 , wherein said multi-component drug tablet is located within a die.

6. The method of claim 3 , wherein said multi-component drug tablet is located out of a die.

7. A system for monitoring or characterizing a multi-component drug tablet during compaction comprising:
a first transducer configured to transmit a first set of acoustic waves into a multi-component drug tablet and to receive a second set of acoustic waves from said multi-component drug tablet while the multi-component drug tablet is being formed in a die during compaction;
a digitizing oscilloscope configured to receive and analyze second set of acoustic wave data from said first transducer;
a non-transitory computer-readable storage medium having program code executable by a processor for calculating a resonance frequency and mode shape of said multi-component drug tablet based on said analyzed data, and for determining a quality level or a defect state of said multi-component drug tablet based on said calculated resonance frequency and mode shape of said multi-component drug tablet.

8. The system of claim 7 , wherein said non-transitory computer-readable storage medium further has program code executable by a processor for comparing said calculated resonance frequency and mode shape of said multi-component drug tablet with an original resonance frequency and mode shape of said multi-component drug tablet.

9. The system of claim 8 , wherein said multi-component drug tablet is located within a die.

10. The system of claim 9 , wherein said transducer is located within said die.

11. The system of claim 10 , further comprising a second transducer located within said die.

12. The system of claim 11 , wherein said first transducer and said second transducer are in a pulse-echo or a pitch-catch configuration.

13. The system of claim 8 , wherein said multi-component drug tablet is located out of a die.

14. The system of claim 8 , further comprising a vibroacoustic excitation and receiver unit configured to transmit a vibratory sound stimulus to said first transducer.

15. The system of claim 14 , wherein said vibroacoustic excitation and receiver unit is configured to receive second set of acoustic wave data from said first transducer, and to transmit said second set of acoustic wave data to said digitizing oscilloscope.

Assignees

• Cetinkaya Cetin
• Univ Clarkson

Inventors

• Cetinkaya Cetin

Classifications

• B30B11/005 Primary

  Control arrangements · CPC title

• G01N29/12 Primary

  by measuring frequency or resonance of acoustic waves {(measuring frequency or resonant frequency of mechanical vibrations or acoustic waves in general G01H1/06, G01H3/04, G01H13/00; acoustic resonators G10K11/04; vibration or shock testing of structures G01M7/00)} · CPC title