Devices for trapping and controlling microparticles with radiation

Patent metadata

Field	Value
Publication number	US-9739751-B2
Application number	US-201514615169-A
Country	US
Kind code	B2
Filing date	Feb 5, 2015
Priority date	Feb 5, 2015
Publication date	Aug 22, 2017
Grant date	Aug 22, 2017

Abstract

A particle manipulation device includes a substrate and a microchannel included in the substrate and configured to receive a fluid including particles therein. A biasing structure is formed on the substrate adjacent to, but outside the microchannel. The biasing structure is configured to dispense radiation at a frequency to bias movement of the particles within the microchannel from outside the microchannel.

First claim

What is claimed is:

1. A particle manipulation device, comprising:
a substrate;
a microchannel included in the substrate and configured to receive a fluid including particles therein; and
at least one biasing structure comprising an antenna formed on the substrate adjacent to but outside the microchannel, the at least one biasing structure configured to generate radiation at a frequency to bias movement of the particles within the microchannel from outside the microchannel.

2. The device as recited in claim 1 , wherein the microchannel includes a plurality of paths configured to separate particles biased by the biasing structures.

3. The device as recited in claim 1 , wherein the microchannel includes at least one chamber for trapping particles biased by the biasing structures.

4. The device as recited in claim 1 , wherein the microchannel includes at least one chamber for detecting particles, and the device further comprises an image sensor configured to detect characteristics of the particles in the at least one chamber.

5. The device as recited in claim 1 , wherein the microchannel is integrated in a removable region that is separable from the substrate.

6. The device as recited in claim 1 , wherein the at least one biasing structure includes at least one solid state diode source configured to use the generated radiation to apply dielectrophoresis forces to the particles.

7. The device as recited in claim 1 , wherein the at least one biasing structure generates radiation to apply dielectrophoresis forces to the particles such that the particles are located in a far field region of the radiation.

8. A particle manipulation device, comprising:
a chip including:
a substrate;
a microchannel included in the substrate and configured to receive a fluid including particles therein;
at least one biasing structure comprising an antenna formed on the substrate adjacent to but outside the microchannel, the at least one biasing structure configured to generate radiation at a frequency to bias movement of the particles within the microchannel from outside the microchannel; and

a control module including:
a generation circuit configured to generate a signal for exciting the biasing structures.

9. The device as recited in claim 8 , wherein the microchannel includes one or more of: a plurality of paths configured to separate particles biased by the biasing structures; at least one chamber for trapping particles biased by the biasing structures; or at least one chamber for detecting particles.

10. The device as recited in claim 8 , wherein the control module and the chip are integrated on the substrate.

11. The device as recited in claim 8 , wherein the control module and the chip are integrated together on a monolithic substrate.

12. The device as recited in claim 8 , wherein the chip includes a detection structure integrated on the substrate and control module includes a detector interface for providing feedback to adjust the at least one biasing structure.

13. The device as recited in claim 12 , wherein the detection structure includes at least one antenna configured to detect characteristics of particles in the microchannel.

14. The device as recited in claim 8 , wherein the at least one biasing structure includes at least one solid state diode source configured to generate radiation to apply dielectrophoresis forces to the particles.

15. The device as recited in claim 8 , wherein the at least one biasing structure generates radiation to apply dielectrophoresis forces to the particles such that the particles are located in a far field region of the radiation.

16. A method for particle manipulation, comprising:
introducing a fluid having particles therein to a microchannel included in a substrate and configured to receive the fluid having the particles therein; and
biasing the particles traveling in the microchannel using at least one biasing structure comprising an antenna formed on the substrate adjacent to but outside the microchannel, the at least one biasing structure being configured to generate radiation at a frequency to bias movement of the particles within the microchannel from outside the microchannel.

17. The method as recited in claim 16 , wherein the microchannel includes one or more paths and chamber configured to trap, separate or redirect particles biased by the biasing structures.

18. The method as recited in claim 16 , further comprising detecting particles using a sensor configured to detect characteristics of the particles.

19. The method as recited in claim 16 , wherein the microchannel is separable from the substrate, and the method further comprising disposing of the microchannel after use.

20. The method as recited in claim 16 , wherein the at least one biasing structure includes at least one solid state diode source, the method further comprising generating radiation to apply dielectrophoresis forces to the particles.

21. The method as recited in claim 16 , wherein the at least one biasing structure generates radiation to apply dielectrophoresis forces to the particles such that the particles are located in a far field region of the radiation.

22. The device as recited in claim 3 , wherein the biasing structures are configured to trap the particle in a position within the at least one chamber.

23. The method as recited in claim 17 , wherein the biasing structures are configured to trap the particle in a position within the one or more paths and chamber.

24. The device as recited in claim 1 , wherein the antenna comprises a resonant tunneling diode.

25. The device as recited in claim 8 , wherein the antenna comprises a resonant tunneling diode.

Assignees

• IBM

Inventors

• Tirapu Azpiroz Jaione

Classifications

• B01L2200/0647

  Handling flowable solids, e.g. microscopic beads, cells, particles · CPC title

• B01L2300/0864

  comprising only one inlet and multiple receiving wells, e.g. for separation, splitting · CPC title

• B03C5/02

  Separators · CPC title

• B03C5/005

  Dielectrophoresis, i.e. dielectric particles migrating towards the region of highest field strength · CPC title

• B01L2300/0816

  Cards, e.g. flat sample carriers usually with flow in two horizontal directions · CPC title