Fluid processing tube capable of being used in optical analysis and method for optically analyzing a fluid

Patent metadata

Field	Value
Publication number	US-9739704-B2
Application number	US-201113990692-A
Country	US
Kind code	B2
Filing date	Nov 23, 2011
Priority date	Dec 8, 2010
Publication date	Aug 22, 2017
Grant date	Aug 22, 2017

Abstract

Fluid processing tube for use in optical analysis comprising at least one first portion being made from a first material suitable for optical analysis and being configured to include two optical paths of different lengths, and at least one second portion connected to said first portion and being made from a second material different from said first material.

First claim

The invention claimed is:

1. A fluid processing tube capable of being used in optical analysis, comprising:
a) a first portion being made from a first material suitable for optical analysis and being configured to include two optical paths of different lengths, and
b) a second portion connected to said first portion and being made from a second material different from said first material,
wherein said first portion comprises an optical detection zone,
wherein said optical detection zone has a rectangular cross-section when viewed in direction of a longitudinal axis of the tube and includes two optical paths of different lengths,
wherein the two optical paths are perpendicular to each other and perpendicular to the longitudinal axis of the tube,
wherein said first portion is configured to contain a fluid,
wherein said fluid processing tube is configured for centrifugation,
wherein said second portion is cylindrically shaped and has a tapered end which contains a combination of protrusions and grooves, and
wherein said first portion is mechanically interlocked to the tapered end of said second portion by the combination of protrusions and grooves.

2. The fluid processing tube according to claim 1 , wherein the first portion is integral with the second portion.

3. The fluid processing tube according to claim 1 , wherein the first portion and the second portion are welded, fused, bonded, form-fitted, frictional-fitted, or any combination thereof, to each other.

4. The fluid processing tube according to claim 1 , wherein the first portion is connected to the second portion over at least one third portion.

5. The fluid processing tube according to claim 1 , wherein said second portion comprises a cap.

6. The fluid processing tube according to claim 5 , wherein said second portion further comprises a connector for connecting the cap to the fluid containing part of the tube over a joint.

7. The fluid processing tube according to claim 5 , wherein said cap is connected to the fluid containing part of the tube over a joint.

8. The fluid processing tube according to claim 5 , wherein said tube and/or said cap comprise at least one cap fixture for holding said cap when being closed.

9. The fluid processing tube according to claim 1 , wherein said first material is suitable for optical analysis in the wavelengths of from 220 to 400 nm.

10. The fluid processing tube according to claim 9 , wherein said first material is suitable for optical analysis in the wavelengths of from 220 to 380 nm.

11. The fluid processing tube according to claim 9 , wherein said first material is suitable for optical analysis in the wavelengths of 230 nm, 260 nm, 280 nm, or any combination thereof.

12. The fluid processing tube according to claim 1 , wherein said optical detection zone is positioned at an end of the tube which is opposite an opening thereof.

13. The fluid processing tube according to claim 1 , wherein a side-wall of the optical detection zone comprises at least one planar area.

14. The fluid processing tube according to claim 1 , wherein the length of the longest optical path is at least three times the length of the shortest optical path.

15. The tube according to claim 1 , wherein said second material is softer and/or less brittle than said first material.

16. The tube according claim 1 , wherein said first material is selected from the group consisting of cyclic olefin copolymers, cyclic olefin polymers, polymethylpenten, glass, graphene and PTFE, and wherein said second material is polypropylene or polyethylene.

17. The tube according to claim 1 , wherein an inner volume of the optical detection zone is approximately 15 microliters or less.

18. A method for optically analyzing a fluid, comprising:
a) filling a liquid into a tube according to claim 1 , and
b) optically analyzing said fluid in the tube.

19. A tube according to claim 1 , capable of being used for processing, optically analysing, storing a fluid, or any combination thereof.

20. The fluid processing tube according to claim 1 , wherein said first portion is distal to said second portion.

21. The fluid processing tube according to claim 1 , wherein said first portion is distal to said second portion.

22. A fluid processing tube capable of being used in optical analysis, comprising:
a) a first portion suitable for optical analysis and being configured to contain a fluid, and
b) a second portion connected to said first portion being configured to include a cap for closing the first portion, wherein
c) the cap is connected to the first portion over a joint,
wherein said first portion comprises an optical detection zone,
wherein said first portion is configured to include two optical paths of different lengths,
wherein the two optical paths are perpendicular to each other and perpendicular to the longitudinal axis of the tube,
wherein said fluid processing tube is configured for centrifugation,
wherein said second portion is cylindrically shaped and has a tapered end which contains a combination of protrusions and grooves, and
wherein said first portion is mechanically interlocked to the tapered end of said second portion by the combination of protrusions and grooves.

23. The tube according to claim 22 , wherein said first portion and said second portion comprise the same material.

24. The tube according to claim 22 , wherein said first portion comprises a first material suitable for optical analysis and said second portion comprises a second material less brittle than said first material.

Assignees

• Voit Thomas
• Geissler Michael
• Quintel Harald
• Gruler Roman
• Qiagen Gmbh

Inventors

• Voit Thomas
• Geissler Michael
• Quintel Harald
• Gruler Roman

Classifications

• G01N2021/0378

  Shapes · CPC title

• B01L2300/047

  Additional chamber, reservoir · CPC title

• G01N2201/066

  Modifiable path; multiple paths in one sample · CPC title

• B01L2300/0654

  Lenses; Optical fibres · CPC title

• B01L2300/043

  Hinged closures · CPC title