Compositions and methods for the treatment of neurological disorders

Patent metadata

Field	Value
Publication number	US-9738631-B2
Application number	US-201314533113-A
Country	US
Kind code	B2
Filing date	Jan 28, 2013
Priority date	May 7, 2012
Publication date	Aug 22, 2017
Grant date	Aug 22, 2017

Abstract

The invention relates to the compounds of formula I and formula IA or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I and formula IA; and methods for treating or preventing neurological diseases may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of epilepsy, bipolar disorder, trigeminal neuralgia, attention-deficit hyperactivity disorder (ADHD), schizophrenia, neuropathic pain, seizures, bipolar disorder, mania, phantom limb syndrome, complex regional pain syndrome, paroxysmal extreme pain disorder, neuromyotonia, intermittent explosive disorder, borderline personality disorder, Myotonia congenita and post-traumatic stress disorder.

First claim

The invention claimed is:

1. A compound of Formula I:

or a pharmaceutically acceptable salt, hydrate, enantiomer, or stereoisomer thereof, wherein:
R 1 represents —O—;
R 3 represents

R 2 represents CH 3 CO—,

a is 2, 3 or 7;
each b is independently 3, 5 or 6;
e is 1, 2 or 6;
c and d are each independently H, D, —OH, —OD, C 1 -C 6 -alkyl, —NH 2 or —COCH 3 .

2. A compound of Formula IA:

or a pharmaceutically acceptable salt, hydrate, enantiomer, or stereoisomer thereof, wherein:
R 1 represents —O—;
R 3 represents

R 2 represents CH 3 CO—,

a is 2, 3 or 7;
each b is independently 3, 5 or 6;
e is 1, 2 or 6;
c and d are each independently H, D, —OH, —OD, C 1 -C 6 -alkyl, —NH 2 or —COCH 3 .

3. A pharmaceutical composition comprising a compound of claim 1 , and a pharmaceutically acceptable carrier.

4. A pharmaceutical composition comprising a compound of claim 2 and a pharmaceutically acceptable carrier.

5. A method of treating epilepsy, trigeminal neuralgia, or neuropathic pain wherein the method comprises administering to a patient in need thereof a therapeutically effective amount of the pharmaceutical composition of claim 3 , and wherein an effective of said pharmaceutical composition is administered to the patient in need by oral administration, delayed release or sustained release, transmucosal administration, syrup, topical administration, parenteral administration, injection, subdermal administration, oral solution, rectal administration, buccal administration or transdermal administration.

6. A method of treating epilepsy, trigeminal neuralgia, or neuropathic pain wherein the method comprises administering to a patient in need thereof a therapeutically effective amount of the pharmaceutical composition of claim 4 , and wherein an effective of said pharmaceutical composition is administered to the patient in need by oral administration, delayed release or sustained release, transmucosal administration, syrup, topical administration, parenteral administration, injection, subdermal administration, oral solution, rectal administration, buccal administration or transdermal administration.

7. The pharmaceutical composition of claim 3 , further comprising a molecular conjugate of carboxamide compounds selected from a group consisting of 5H-dibenzo[b,f]azepine-5-carboxamide and 10-oxo-10,11-dihydro-5H-dibenzo[b,f]azepine-5-carboxamide, and carboxylic acid compounds selected from a group consisting of R-Lipoic acid, eicosapentaenoic acid and docosahexaenoic acid.

8. The pharmaceutical composition of claim 7 , wherein the carboxylic acid compound is R-Lipoic acid.

9. The pharmaceutical composition of claim 7 , wherein the carboxylic acid compound is eicosapentaenoic acid.

10. The pharmaceutical composition of claim 7 , wherein the carboxylic acid compound is docosahexaenoic acid.

11. The pharmaceutical composition of claim 7 , wherein the carboxamide compound is 5H-dibenzo[b,f]azepine-5-carboxamide.

12. The pharmaceutical composition of claim 7 , wherein the carboxamide compound is 10-oxo-10,11-dihydro-5H-dibenzo[b,f]azepine-5-carboxamide.

13. The pharmaceutical composition of claim 4 , further comprising a molecular conjugate of carboxamide compounds selected from a group consisting of 5H-dibenzo[b,f]azepine-5-carboxamide and 10-oxo-10,11-dihydro-5H-dibenzo[b,f]azepine-5-carboxamide, and carboxylic acid compounds selected from a group consisting of R-Lipoic acid, eicosapentaenoic acid and docosahexaenoic acid.

14. The pharmaceutical composition of claim 13 , wherein the carboxylic acid compound is R-Lipoic acid.

15. The pharmaceutical composition of claim 13 , wherein the carboxylic acid compound is eicosapentaenoic acid.

16. The pharmaceutical composition of claim 13 , wherein the carboxylic acid compound is docosahexaenoic acid.

17. The pharmaceutical composition of claim 13 , wherein the carboxamide compound is 5H-dibenzo[b,f]azepine-5-carboxamide.

18. The pharmaceutical composition of claim 13 , wherein the carboxamide compound is 10-oxo-10,11-dihydro-5H-dibenzo[b,f]azepine-5-carboxamide.

Assignees

• Cellix Bio Private Ltd
• Cellix Bio Private Ltd

Inventors

• Kandula Mahesh

Classifications

• A61P25/28

  for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia · CPC title

• A61P25/20

  Hypnotics; Sedatives · CPC title

• A61P25/18

  Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia · CPC title

• A61P25/08

  Antiepileptics; Anticonvulsants · CPC title

• A61P25/04

  Centrally acting analgesics, e.g. opioids · CPC title