Nicotine salts, co-crystals, and salt co-crystal complexes

Patent metadata

Field	Value
Publication number	US-9738622-B2
Application number	US-201514721283-A
Country	US
Kind code	B2
Filing date	May 26, 2015
Priority date	May 27, 2014
Publication date	Aug 22, 2017
Grant date	Aug 22, 2017

Abstract

The invention provides certain nicotine salts, co-crystals, and salt co-crystals and provides novel polymorphic forms of certain nicotine salts. In particular, nicotine salts with mucic acid, 3,5-dihydroxybenzoic acid, and 2,3-dihydroxybenzoic acid, and crystalline polymorphic forms of nicotine 4-acetamidobenzoate, nicotine gentisate, and nicotine 1-hydroxy-2-naphthoate are described. The invention further provides methods of preparation and characterization of such nicotine salts, co-crystals, and salt co-crystals and polymorphic forms thereof. In addition, tobacco products, including smoking articles, smokeless tobacco products, and electronic smoking articles comprising nicotine salts, co-crystals, and/or salt co-crystals are also provided.

First claim

What is claimed:

1. A salt of nicotine and mucic acid, characterized by an X-ray powder diffraction pattern having peaks at one or more of the following 2-theta diffraction angles: 14.289, 15,449, 19.66, and 20.412.

2. The salt of claim 1 , wherein at least 50% of the salt or is in crystalline form.

3. A pharmaceutical product comprising a composition comprising the salt of claim 1 and one or more excipients selected from the group consisting of salts, sweeteners, fillers, flavorants, antiadherents, glidants, preservatives, antioxidants, surfactants, dyes, pigments, lubricants, and processing aids.

4. The pharmaceutical product of claim 3 , in a form selected from the group consisting of a pill, tablet, lozenge, capsule, caplet, pouch, gum, inhaler, solution, and cream.

Assignees

• Reynolds Tobacco Co R

Inventors

• Dull Gary M
• Carr Andrew
• Sharp Emma

Classifications

• A61P9/12

  Antihypertensives · CPC title

• A61P27/04

  Artificial tears; Irrigation solutions · CPC title

• A61P25/34

  Tobacco-abuse · CPC title

• A61P25/28

  for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia · CPC title

• A61P25/26

  Psychostimulants, e.g. nicotine, cocaine · CPC title