Crystalline particles of salts of glutamic acid N,N-diacetic acid

Patent metadata

Field	Value
Publication number	US-9738594-B2
Application number	US-201314649361-A
Country	US
Kind code	B2
Filing date	Dec 12, 2013
Priority date	Dec 14, 2012
Publication date	Aug 22, 2017
Grant date	Aug 22, 2017

Abstract

The invention relates to a salt of glutamic acid-N,N-diacetic acid (GLDA) of the formula GLDA-Y m H n , wherein m is equal to or more than 0.5 and lower than or equal to 2.5, n+m=4, and wherein Y is a monovalent cation that is not a proton, comprising L-GLDA-Y m H n to D-GLDA-Y m H n in a range between 100:0 and 50:50 (L:D), characterized in that the salt is crystalline, a process to make such crystalline salt, and to uses of such salt, such as, in particular, in detergent compositions.

First claim

The invention claimed is:

1. Salt of glutamic acid-N,N-diacetic acid (GLDA) of the formula GLDA-Y m H n , wherein m is equal to or more than 0.5 and lower than or equal to 2.5, n+m=4, and wherein Y is a monovalent cation that is not a proton, comprising L-GLDA-Y m H n to D-GLDA-Y m H n in a range between 100:0 and 50:50 (L:D), characterized in that the salt is crystalline.

2. Salt of the formula GLDA-Y m H n according to claim 1 , wherein Y is an alkali metal.

3. Salt of the formula GLDA-Y m H n according to claim 1 , wherein m is about 1 and n is about 3.

4. Salt of the formula GLDA-Y m H n according to claim 1 , wherein the salt comprises L-GLDA-Y m H n : D-GLDA-Y m H n between 75:25 and 50:50 (L:D).

5. Process to prepare the salt of the formula GLDA-Y m H n according to claim 1 , comprising:
a first step providing an aqueous solution containing a salt of GLDA and/or GLDA-H 4 ,
a second step ensuring that the pH of the aqueous solution is equal to or more than 1.8 and less than 5 and performing a racemization step to at least partially racemize the salt of GLDA, one step after the other in random order or simultaneously, and
a third step allowing the aqueous solution to crystallize.

6. Process according to claim 5 , wherein the pH of the second step is in the range between 1.8 and 4.8.

7. Process according to claim 5 , wherein the second step includes a concentrating step.

8. Process according to claim 7 , wherein the concentrating step is carried out until the solution has a concentration of equal to or more than 15 wt % up to or equal to 80 wt %, of GLDA-Y m H n based on the weight of the aqueous solution.

9. Process according to claim 5 , wherein the third step comprises crystallization accomplished by a step selected from the group consisting of allowing the solution to stand until the solution crystallizes, cooling, and seeding.

10. Process according to claim 5 , wherein the third step comprises spraying the aqueous solution of the second step on seeding crystals.

11. Process according to claim 5 , wherein the third step is performed at a temperature of equal to or below 30° C.

12. Process according to claim 5 , wherein the process is a continuous process.

13. Process according to claim 5 , comprising an additional step wherein carbonates, silicates, or a combination of carbonates and silicates are added to the resulting product of the third step, so that the pH of an aqueous solution of the resulting product is above 6.

14. Detergent compositions containing the salt of the formula GLDA-Y m H n according to claim 1 , and further comprising at least one component selected from the group consisting of cleaning additives, antiscaling additives, builders, protective colloids, chelating agents, surfactants, corrosion inhibitors, and inorganic or organic acids.

15. Pharmaceutical preparations containing the salt of the formula GLDA-Y m H n according to claim 1 , and further comprising a pharmaceutically acceptable carrier.

Assignees

• Akzo Nobel Chemicals Int Bv

Inventors

• Doppen Roy Gérard
• Heus Martin
• Van Lare Cornelis Elizabeth Johannus

Classifications

• C11D3/33

  Amino carboxylic acids · CPC title

• C07B2200/13

  Crystalline forms, e.g. polymorphs · CPC title

• C07C227/42

  Crystallisation · CPC title

• C07C229/24 Primary

  having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid · CPC title

• C07C229/76 Primary

  Metal complexes of amino carboxylic acids · CPC title