Topical gels and methods of using the same

Patent metadata

Field	Value
Publication number	US-9737561-B2
Application number	US-201615353301-A
Country	US
Kind code	B2
Filing date	Nov 16, 2016
Priority date	Aug 21, 2009
Publication date	Aug 22, 2017
Grant date	Aug 22, 2017

Abstract

Provided according to some embodiments of the invention are topical gels that may release nitric oxide. Also provided are methods of using such topical gels in the treatment of wounds and other skin ailments.

First claim

We claim:

1. A method of treating a skin ailment in a subject, the method comprising:
administering to a subject a topical composition comprising nitric oxide-releasing polysiloxane macromolecules and
a hydrophobic, non-aqueous gel base, the hydrophobic, non-aqueous gel base comprising mineral oil, wherein the nitric oxide (NO) storage per gram is in a range of 100 nmol NO/g to 1 mmol NO/g of the topical composition and at least 70% of NO of the nitric oxide-releasing polysiloxane macromolecule remains in the topical composition two days after initial formulation when the topical composition is stored at room temperature.

2. The method of claim 1 , wherein the nitric oxide-releasing polysiloxane macromolecules are diazeniumdiolate-functionalized polysiloxane macromolecules.

3. The method of claim 1 , wherein the method decreases inflammation in the subject.

4. The method of claim 1 , wherein the method decreases inflammatory response factors in the subject.

5. The method of claim 1 , wherein the method modulates inflammatory cytokines in the subject.

6. The method of claim 1 , wherein the skin ailment is an inflammatory skin condition.

7. The method of claim 1 , wherein the skin ailment is impetigo, psoriasis, tinea pedis, or onychomycosis.

8. The method of claim 1 , wherein the topical composition is antimicrobial.

9. The method of claim 1 , wherein the topical composition disperses a biofilm.

10. The method of claim 1 , wherein the topical composition disrupts the structure of the biofilm and/or prevents biofilm formation.

11. The method of claim 1 , wherein the topical composition kills bacteria present in a biofilm.

12. A method of treating a skin ailment in a subject, the method comprising:
administering to a subject a topical composition comprising nitric oxide-releasing polysiloxane macromolecules and a hydrophilic gel base, the hydrophilic gel base comprising an alcohol, wherein the nitric oxide (NO) storage per gram is in a range of 100 nmol NO/g to 1 mmol NO/g of the topical composition and at least 70% of NO of the nitric oxide-releasing polysiloxane macromolecule remains in the topical composition two days after initial formulation when the topical composition is stored at room temperature.

13. The method of claim 12 , wherein the nitric oxide-releasing polysiloxane macromolecules are diazeniumdiolate-functionalized polysiloxane macromolecules.

14. The method of claim 12 , wherein the method decreases inflammation in the subject.

15. The method of claim 12 , wherein the method decreases inflammatory response factors in the subject.

16. The method of claim 12 , wherein the method modulates inflammatory cytokines in the subject.

17. The method of claim 12 , wherein the skin ailment is an inflammatory skin condition.

18. The method of claim 12 , wherein the skin ailment is impetigo, psoriasis, tinea pedis, or onychomycosis.

19. The method of claim 12 , wherein the topical composition is antimicrobial.

20. The method of claim 12 , wherein the topical composition disperses a biofilm.

21. The method of claim 12 , wherein the topical composition disrupts the structure of the biofilm and/or prevents biofilm formation.

22. The method of claim 12 , wherein the topical composition kills bacteria present in a biofilm.

Assignees

• Novan Inc

Inventors

• Stasko Nathan
• Bauman Susanne
• Joshi Pranav R

Classifications

• A61P31/00

  Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics · CPC title

• A61P17/02

  for treating wounds, ulcers, burns, scars, keloids, or the like · CPC title

• A61P17/10

  Anti-acne agents · CPC title

• A61K31/655

  Azo (—N=N—), diazo (=N2), azoxy (>N—O—N< or N(=O)—N<), azido (—N3) or diazoamino (—N=N—N<) compounds · CPC title

• A61K9/0014

  Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00) · CPC title