Method of treating or preventing pathologic effects of acute increases in hyperglycemia and/or acute increases of free fatty acid flux

Patent metadata

Field	Value
Publication number	US-9737511-B2
Application number	US-29780805-A
Country	US
Kind code	B2
Filing date	Dec 7, 2005
Priority date	May 24, 2004
Publication date	Aug 22, 2017
Grant date	Aug 22, 2017

Abstract

One aspect of the present invention relates to a method of treating or preventing pathologic effects of hyperglycemia and/or increased fatty acid flux in a subject in need of such treatment or preventive therapy. This method involves administering a composition containing a therapeutically effective amount of a ROS inhibitor to a subject in need thereof.

First claim

What is claimed:

1. A method of treating diminished ischemia-induced neovascularization in a diabetic subject consisting of:
a) measuring diminished ischemia-induced neovascularization in a diabetic subject: and
b) transdermally administering to the diabetic subject a pharmaceutical composition consisting of deferoxamine in a sterile diluent or consisting of deferoxamine in solution with a pharmaceutically acceptable salt, liquid carrier, excipient, or stabilizer, in an amount effective to increase neovascularization.

2. The method of claim 1 , wherein said deferoxamine is in a solution with a liquid glycol carrier.

3. The method of claim 1 , wherein said deferoxamine is in sterile saline.

Assignees

• Gurtner Geoffrey C
• Brownlee Michael A
• Albert Einstein College Medicine Inc

Inventors

• Gurtner Geoffrey C
• Brownlee Michael A

Classifications

• A61K31/496

  Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin · CPC title

• A61K31/5377

  not condensed and containing further heterocyclic rings, e.g. timolol · CPC title

• A61K31/4196 Primary

  1,2,4-Triazoles · CPC title

• A61P3/10

  for hyperglycaemia, e.g. antidiabetics · CPC title