Method of regulating circadian rhythm, and method of preparing circadian rhythm regulatory agent

Patent metadata

Field	Value
Publication number	US-9737494-B2
Application number	US-201514676265-A
Country	US
Kind code	B2
Filing date	Apr 1, 2015
Priority date	May 15, 2012
Publication date	Aug 22, 2017
Grant date	Aug 22, 2017

Abstract

Disclosed are a method of preparation and method of application of a circadian rhythm regulatory agent having as an active ingredient an alkylresorcinol represented by general formula (I) below and a circadian rhythm regulatory agent containing as an active ingredient an alkylresorcinol-containing extract from a cereal or a nut containing an alkylresorcinol of the following general formula (I). In the following general formula (I), R 1 is a saturated or unsaturated alkyl group; and R 2 is hydrogen or methyl. In general formula (I), R 1 is preferably at the para-position with respect to R 2 , and R 1 is preferably a saturated or unsaturated alkyl group having 15 to 27 carbon atoms.
[Chem. 1]

First claim

The invention claimed is:

1. A method of regulating the circadian rhythm of a human, comprising steps of:
providing a pharmaceutical composition, comprising as an active ingredient a plant extract comprising an alkylresorcinol of general formula (1):

wherein R 1 is a saturated or unsaturated C15-C27 alkyl group; and R 2 is a hydrogen atom or a methyl group; and
administering to said human an effective amount in a range of 0.01 to 10 g per day of the pharmaceutical composition.

2. The method according to claim 1 , wherein the plant extract comprises a combination of:
1,3-Dihydroxy-5-n-pentadecylbenzene,
1,3-Dihydroxy-5-n-heptadecylbenzene,
1,3-Dihydroxy-5-n-nonadecylbenzene,
1,3-Dihydroxy-5-n-heneicosylbenzene,
1,3-Dihydroxy-5-n-tricosylbenzene, and
1,3-Dihydroxy-5-n-pentacosylbenzene.

Assignees

• Aist
• Nisshin Seifun Group Inc
• Oriental Yeast Co Ltd
• Nat'L Inst Of Advanced Ind Science & Tech
• Oriental Yeast Co Ltd

Inventors

• Oishi Katsutaka
• MIYAZAKI Koyomi
• Onishi Yoshiaki
• Tomita Tatsunosuke
• ITOH Nanako
• Fukudome Shinichi
• Tanaka Keiko
• Kikuchi Yosuke
• Kasuya Kenji

Classifications

• C07C39/08

  Dihydroxy benzenes; Alkylated derivatives thereof · CPC title

• A61P25/20

  Hypnotics; Sedatives · CPC title

• A61P25/02

  for peripheral neuropathies · CPC title

• A61K2236/33

  involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones · CPC title

• A61K36/185

  Magnoliopsida (dicotyledons) · CPC title