Methods for treating hair loss disorders

Patent metadata

Field	Value
Publication number	US-9737469-B2
Application number	US-201615066479-A
Country	US
Kind code	B2
Filing date	Mar 10, 2016
Priority date	Nov 2, 2010
Publication date	Aug 22, 2017
Grant date	Aug 22, 2017

Abstract

The invention provides for methods for treating a hair loss disorder in a subject by administering a Janus Kinase/Signal Transducers and Activators of Transcription inhibitor.

First claim

What is claimed is:

1. A method of treating a hair-loss disorder in a mammalian subject in need thereof, the method comprising administering to the subject an effective amount of an inhibitor of Janus Kinase (Jak)1, Jak2, or Jak3, wherein said inhibitor is LY3009104.

2. The method of claim 1 , wherein the hair-loss disorder comprises androgenetic alopecia, telogen effluvium, alopecia areata, telogen effluvium, tinea capitis, hypotrichosis, or hereditary hypotrichosis simplex.

3. The method of claim 2 , wherein the alopecia areata is alopecia totalis or alopecia universalis.

4. The method of claim 1 wherein the subject is a human.

5. The method of claim 4 wherein the hair loss-disorder is androgenetic alopecia.

6. The method of claim 1 wherein the hair loss-disorder is alopecia areata.

7. A method for inducing hair growth in a subject, the method comprising:
(a) administering to the subject an effective amount of a Jak1, Jak2, or Jak3 inhibitor, wherein said inhibitor is LY3009104,
thereby inducing hair growth in the subject.

8. The method of claim 7 , wherein the subject suffers from a hair-loss disorder, wherein the hair-loss disorder is selected from—androgenetic alopecia, telogen effluvium, alopecia areata, telogen effluvium, tinea capitis, hypotrichosis, and hereditary hypotrichosis simplex.

9. The method of claim 8 , wherein the alopecia areata is alopecia totalis or alopecia universalis.

10. The method of claim 8 wherein the hair loss-disorder is androgenetic alopecia.

11. The method of claim 8 wherein the hair loss-disorder is alopecia areata.

Assignees

• Univ Columbia

Inventors

• Christiano Angela M
• Clynes Raphael

Classifications

• A61K2800/782

  Enzyme inhibitors; Enzyme antagonists · CPC title

• A61K31/7052

  having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides · CPC title

• A61K31/5377

  not condensed and containing further heterocyclic rings, e.g. timolol · CPC title

• A61Q7/00

  Preparations for affecting hair growth · CPC title

• A61K31/437

  the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline · CPC title