Systems and methods for reducing scarring

Patent metadata

Field	Value
Publication number	US-9737395-B2
Application number	US-201514751396-A
Country	US
Kind code	B2
Filing date	Jun 26, 2015
Priority date	Jun 26, 2015
Publication date	Aug 22, 2017
Grant date	Aug 22, 2017

Abstract

Systems and methods are disclosed to protect a medical device from scarring a body after implanting the device in the body by creating a bonding matrix on a surface of the device; exposing the surface to hyaluronic acid (HA) or polyethylene glycol (PEG); cross linking the HA or PEG; and preventing capsular contracture after implanting the device in the body.

First claim

What is claimed is:

1. A method to protect a medical device from scarring a body after implanting the device in the body, comprising:
swelling a device shell;
allowing hyaluronic acid (HA) to diffuse into a polymer matrix of the shell;
cross-linking the HA while the shell is swollen; and
deswelling the device shell thereafter.

2. The method of claim 1 , comprising forming an interpenetrating network with the HA.

3. The method of claim 1 , comprising cross-linking the HA to an iso-osmotic state.

4. The method of claim 1 , comprising swelling the device shell with tetrahydrofuran (THF) or dichloromethane (DCM).

5. The method of claim 1 , comprising deswelling with water or saline.

6. The method of claim 1 , comprising cross-linking the HA with divinyl sulfide (DVS) or diglycidyl ether (BDDE).

7. The method of claim 1 , wherein the device comprises an implantable medical device.

8. The method of claim 1 , wherein the device comprises a breast implant, a facial implant, a heart valve, a stent, a graft, a cardiovascular graft, an artificial joint, a rod, a knee portion, a skull plate, cranial facial hardware, a heart part, a pacemaker, an electrical lead, a nerve stimulator, a suture.

9. A method to protect a medical device from scarring a body after implanting the device in the body, comprising:
swelling a device shell;
allowing hyaluronic acid (HA) to diffuse into a polymer matrix of the shell;
cross-linking the HA while the shell is swollen; and
deswelling the device shell thereafter; and
preventing capsular contracture after implanting the device in the body.

10. The method of claim 9 , wherein the device comprises an implantable medical device.

11. The method of claim 9 , wherein the device comprises a breast implant, a facial implant, a heart valve, a stent, a graft, a cardiovascular graft, an artificial joint, a rod, a knee portion, a skull plate, cranial facial hardware, a heart part, a pacemaker, an electrical lead, a nerve stimulator, a suture.

12. A method to protect a medical device from scarring a body after implanting the device in the body, comprising:
exposing a device surface to hyaluronic acid (HA) or polyethylene glycol (PEG);
cross linking the HA or PEG;
swelling a device shell;
allowing HA or PEG to diffuse into a polymer matrix of the shell; and
deswelling the device shell thereafter.

13. The method of claim 12 , wherein the device comprises an implantable medical device.

14. The method of claim 12 , wherein the device comprises a breast implant, a facial implant, a heart valve, a stent, a graft, a cardiovascular graft, an artificial joint, a rod, a knee portion, a skull plate, cranial facial hardware, a heart part, a pacemaker, an electrical lead, a nerve stimulator, a suture.

15. The method of claim 12 , comprising cross-linking the HA while the shell is swollen.

Assignees

• Nguyen Phi
• Phan Loc
• Tran Bao

Inventors

• Nguyen Phi
• Phan Loc
• Tran Bao

Classifications

• A61L27/34 Primary

  Macromolecular materials · CPC title

• A61F2/12 Primary

  Mammary prostheses · CPC title

• A61F2210/0076

  multilayered, e.g. laminated structures · CPC title

• A61L27/50

  Materials characterised by their function or physical properties {, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials} · CPC title

• A61F2250/0067

  Means for introducing or releasing pharmaceutical products into the body · CPC title