Composite singularity mapping

Patent metadata

Field	Value
Publication number	US-9737267-B2
Application number	US-201414156951-A
Country	US
Kind code	B2
Filing date	Jan 16, 2014
Priority date	Jan 17, 2013
Publication date	Aug 22, 2017
Grant date	Aug 22, 2017

Abstract

A method can include storing a plurality of data sets including values computed for each of a plurality of points for a given spatial region of tissue, the values in each of the data sets characterizing electrical information for each respective point of the plurality of points for a different time interval. The method can also include combining the values computed for each of a plurality of points in a first interval, corresponding to a first map, with the values for computed for each of the respective plurality of points in another interval and to normalize the combined values relative to a common scale. The method can also include generating a composite map for the given spatial region based on the combined values that are normalized.

First claim

What is claimed is:

1. A non-transitory computer-readable medium having instructions executable by a processor, the instructions comprising:
a composite map generator programmed to:
receive a plurality of data sets including values computed for each of a plurality of points for a given spatial region of tissue, each of the plurality of datasets characterizes electrical information for each of the plurality of points for a different time interval;
combine the values computed for each of a plurality of points over at least two different time intervals; and
normalize the combined values relative to a common scale; and

an output generator programmed to generate a composite map for the given spatial region based on the combined values that are normalized.

2. The medium of claim 1 , wherein the output generator is further programmed to repeat the generating for a plurality of composite maps with increasing numbers of intervals until convergence criteria is satisfied for successive composite maps generated for the given spatial region.

3. The medium of claim 2 , wherein the convergence is determined based on a correlation between the plurality of points of a previous composite map relative to the plurality of points of a next successive composite map.

4. The medium of claim 3 , wherein the correlation is compared relative to a threshold to determine the convergence criteria has been satisfied.

5. The medium of claim 4 , wherein the threshold is predefined or programmable in response to a user input.

6. The medium of claim 1 , wherein the output generator is further programmed to generate a graphical map for each composite map and the first map, each of the graphical maps being presented in a successive order to demonstrate convergence of each singularity in the given spatial region.

7. The medium of claim 6 , wherein the electrical information comprises a characteristic of a cardiac singularity computed by a singularity calculator for each of a plurality of points in the given spatial region.

8. The medium of claim 7 , wherein the cardiac singularity comprises a phase singularity computed by the singularity calculator for each of the plurality of points in the given spatial region.

9. The medium of claim 1 , wherein the given spatial region comprises one of an epicardial region or an endocardial region.

10. The medium of claim 1 , wherein the given spatial region comprises a portion of a cardiac envelope or the entire cardiac envelope.

11. The medium of claim 1 , wherein the values are computed based on electrical data acquired non-invasively for a patient.

12. The medium of claim 1 , wherein the values are computed based on electrical data acquired invasively for the patient.

13. The medium of claim 1 , wherein the combining the values comprises summing the values for each of the plurality of points from the at least two different time intervals.

14. A non-transitory computer-readable medium having instructions executable by a processor to perform a method comprising:
computing values for each of a plurality of points of a geometric surface in a first time interval of a plurality of time intervals and other values for each of the plurality of points of the geometric surface in a second time interval of the plurality of time intervals;
normalizing the values and the other values for each of the plurality of points of the geometric surface to a common scale;
aggregating the normalized values and the normalized other values into aggregated values,
generating a first composite map based on the aggregated values; and
repeating the computing, the normalizing, and the aggregating to generate at least another composite map that includes a respective value computed for each respective point of the plurality of points of the geometric surface until convergence criteria is satisfied for a plurality of successively generated composite maps for the geometric surface.

15. The medium of claim 14 , wherein the aggregating comprises summing values for each respective point in the maps being aggregated.

16. The medium of claim 14 , the method further comprising determining the convergence criteria is satisfied based on computing a correlation between the plurality of points of the geometric surface for each of the successively generated composite maps.

17. The medium of claim 16 , the method further comprising comparing results of the computed correlation relative to a threshold to determine the convergence criteria has been satisfied for at least one singularity.

18. The medium of claim 17 , wherein the threshold is predefined or programmable in response to a user input.

19. The medium of claim 14 , the method further comprising generating a graphical map for each composite map and the first map, the graphical maps being presented in a successive order to demonstrate convergence visually for at least one singularity in the geometric surface.

20. The medium of claim 14 , wherein the value computed for each of the plurality of points comprises a characteristic of a cardiac electrical singularity computed for each of the plurality of points in the surface.

21. The medium of claim 20 , wherein the cardiac singularity comprises an electrical phase singularity computed for each of the plurality of points in the surface.

22. The medium of claim 14 , wherein the geometric surface comprises one of an epicardial region or an endocardial region.

23. The medium of claim 14 , wherein the geometric surface comprises a predefined portion of a cardiac surface or the entire cardiac surface.

24. The medium of claim 14 , the method further comprising computing the values for each of the plurality points of the geometric surface based on electrical data acquired non-invasively for the patient.

25. The medium of claim 14 , the method further comprising computing the values for each of the plurality points of the geometric surface based on electrical data acquired invasively for the patient.

26. The medium of claim 14 , wherein the aggregating further comprises summing the values computed for each respective point of the plurality of points in the plurality of intervals.

27. The medium of claim 14 , the method further comprising determining at least one parameter for delivering a therapy to a patient's heart based on at least one of the composite maps.

28. The medium of claim 27 , wherein the therapy further comprising performing ablation at one or more sites determined based on at least one of the composite maps.

Assignees

• Cardioinsight Technologies Inc

Inventors

• Strom Maria
• Zeng Qingguo
• Dubois Remi
• Jia Ping
• Bokan Ryan
• Vasudevan Venkatesh
• Ramanathan Charulatha
• George Brian P

Classifications

• A61B5/318

  Heart-related electrical modalities, e.g. electrocardiography [ECG] · CPC title

• A61B5/367

  Electrophysiological study [EPS], e.g. electrical activation mapping or electro-anatomical mapping · CPC title

• A61B5/7282 Primary

  Event detection, e.g. detecting unique waveforms indicative of a medical condition (cough events A61B5/0823; seizures A61B5/4094; sleep apnoea A61B5/4818) · CPC title

• A61B5/044

  Human Necessities · mapped topic

• A61B5/0044

  for the heart · CPC title