Selection device for candidate sequence information for similarity determination, selection method, and use for such device and method
US-2015379197-A1 · Dec 31, 2015 · US
Genomic features associated with epigenetic control regions and transgenerational inheritance of epimutations
US9734283B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9734283-B2 |
| Application number | US-201213729175-A |
| Country | US |
| Kind code | B2 |
| Filing date | Dec 28, 2012 |
| Priority date | Dec 30, 2011 |
| Publication date | Aug 15, 2017 |
| Grant date | Aug 15, 2017 |
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Abstract
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CpG densities and sequence motifs that are characteristic of regions of DNA associated with epimutations and control of epimutations are provided. Such regions include, within approximately 400 (or fewer) base pairs, at least one, usually two, and preferably all three of the following features: i) a CpG density of 15% or less; ii) the presence of the sequence motif ATTTGTTTTTTCTTTTnT (SEQ ID NO: 1) where n is A, T, C or G, and statistically relevant variants thereof; and iii) the presence of the sequence motif GGGGGnGGGG (SEQ ID NO: 2), where n is A, T, C or G, and statistically relevant variants thereof.
First claim
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We claim: 1. A method of detecting epimutations and regulatory sites of epimutations, comprising: extracting genomic DNA from a biological sample; sequencing said genomic DNA to obtain at least one genomic DNA sequence; and detecting a plurality of regions of said at least one genomic DNA sequence that contains one or both of epimutations and regulatory sites of epimutations by detecting each of i) and ii) using methylated DNA immunoprecipitation followed by a tiling array or next generation sequencing: i) at least one DNA sequence region with a low density of CpG, wherein said low density of CpG is 10% or less CpG; and ii) at least one DNA sequence motif, wherein said at least one DNA sequence motif includes EDM2. 2. The method of claim 1 , wherein said one or more regions of said at least one genomic DNA sequence are at least 400 base pairs long. 3. The method of claim 1 , wherein said at least one DNA sequence motif includes EDM1. 4. The method of claim 1 , wherein said at least one DNA sequence motif includes EDM1 and EDM2.
Assignees
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Classifications
- G06F19/22Primary
Physics · mapped topic
Methods for sequencing · CPC title
for detection of mutation or polymorphism · CPC title
involving nucleic acids · CPC title
Physics · mapped topic
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- What does patent US9734283B2 cover?
- CpG densities and sequence motifs that are characteristic of regions of DNA associated with epimutations and control of epimutations are provided. Such regions include, within approximately 400 (or fewer) base pairs, at least one, usually two, and preferably all three of the following features: i) a CpG density of 15% or less; ii) the presence of the sequence motif ATTTGTTTTTTCTTTTnT (SEQ ID NO…
- Who is the assignee on this patent?
- Washington State Univ Res Found, Univ Washington State
- What technology area does this patent fall under?
- Primary CPC classification G06F19/22. Mapped technology areas include Physics.
- When was this patent published?
- Publication date Tue Aug 15 2017 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).