Observation of axial magnetization of an object in a magnetic field

Patent metadata

Field	Value
Publication number	US-9733318-B2
Application number	US-201214112674-A
Country	US
Kind code	B2
Filing date	Apr 23, 2012
Priority date	Apr 22, 2011
Publication date	Aug 15, 2017
Grant date	Aug 15, 2017

Abstract

A method of observing axial magnetization (Mz) in an object (O) located in a main magnetic field (B 0 ) comprises the step of determining magnetic field intensity (B p ) in at least one magnetic field probe (P) arranged in the neighborhood of the object. The magnetic field probe comprises a magnetic resonance (MR) active substance, means for pulsed MR excitation of the substance and means for receiving an MR signal generated by said substance.

First claim

The invention claimed is:

1. A method of observing axial magnetization (Mz) in an object (O) located in a main magnetic field (B 0 ), determining magnetic field intensity (B P ) in at least one magnetic field probe (P) arranged in the neighborhood of the object, said magnetic field probe comprising a magnetic resonance (MR) active substance, means for pulsed MR excitation of said substance and means for receiving an MR signal generated by said substance, said step of determining magnetic field intensity (B P ) comprising pulsed excitation of said substance with said means for pulsed MR excitation, said step of determining magnetic field intensity being carried out in a plurality of at least two magnetic field probes (P i , with i=1 to n, n≧2), thereby providing respective magnetic field intensities (B Pi , with i=1 to n, n≧2), said method further comprising the step of subtracting a background magnetic field (B B ) from each one of said respective magnetic field intensities Bpi, said step of determining magnetic field intensity being repeated at a predetermined sampling rate, said sampling rate being up to 100 Hz.

2. The method according to claim 1 , wherein said background magnetic field (B B ) is modeled as a linear combination of preselected basis functions ƒ 1 (r).

3. The method according to claim 2 , wherein said pulsed excitation induces nuclear magnetic resonance of said substance.

4. The method according to claim 2 , further comprising the step of obtaining from said magnetic field intensity (B P ) an observable (Az) that is proportional to said axial magnetization (Mz).

5. The method according to claim 2 , further comprising the step of manipulating nuclear magnetization of an MR active nuclear species in said object by applying at least one radiofrequency field and optionally at least one gradient field before or concomitantly with said observing of axial magnetization (Mz).

6. The method according to claim 1 , wherein said pulsed excitation induces nuclear magnetic resonance of said substance.

7. The method according to claim 6 , further comprising the step of obtaining from said magnetic field intensity (B P ) an observable (Az) that is proportional to said axial magnetization (Mz).

8. The method according to claim 6 , further comprising the step of manipulating nuclear magnetization of an MR active nuclear species in said object by applying at least one radiofrequency field and optionally at least one gradient field before or concomitantly with said observing of axial magnetization (Mz).

9. The method according to claim 6 , further comprising the step of manipulating nuclear magnetization of an MR active nuclear species in said object by applying at least one radiofrequency field and optionally at least one gradient field before or concomitantly with said observing of axial magnetization (Mz).

10. The method according to claim 1 , further comprising the step of obtaining from said magnetic field intensity (B P ) an observable (Az) that is proportional to said axial magnetization (Mz).

11. The method according to claim 10 , further comprising the step of manipulating nuclear magnetization of an MR active nuclear species in said object by applying at least one radiofrequency field and optionally at least one gradient field before or concomitantly with said observing of axial magnetization (Mz).

12. The method according to claim 1 , further comprising the step of manipulating nuclear magnetization of an MR active nuclear species in said object by applying at least one radiofrequency field and optionally at least one gradient field before or concomitantly with said observing of axial magnetization (Mz).

13. The method according to claim 12 , further comprising the step of determining a nuclear relaxation property of said MR active nuclear species from the temporal behavior of said observed axial magnetization (Mz).

14. The method according to claim 1 , wherein the object of interest is a material sample, a water sample, a sample of body liquid, a cell culture, or a plant or part thereof.

15. The method according to claim 1 , wherein the object of interest is a live human or animal, wherein said at least one magnetic field probe is mounted on a chest region, for observing field fluctuations caused by the beating heart.

16. The method according to claim 1 , wherein the object of interest is a live human or animal, wherein said observing of axial magnetization (Mz) is used to control an MRI procedure carried out in said main magnetic field.

17. The method according to claim 1 , wherein the object of interest is a live human or animal, wherein said observing of axial magnetization (Mz) is used to monitor status and/or compliance of said human or animal.

18. The method according to claim 1 wherein the object of interest is a live human or animal, wherein said observing of axial magnetization (Mz) is used to to support signal processing anellor image reconstruction.

19. The method according to claim 1 , wherein the object of interest is a live human or animal, wherein said at least one magnetic field probe is mounted on a head region, wherein said observing of axial magnetization (Mz) is used to observe field fluctuations caused by physiological processes in the brain.

Assignees

• Prussmann Klaas
• Barmet Christoph
• Eidgenossische Technische Hochschule (Eth)
• Univ Zuerich

Inventors

• Prussmann Klaas
• Barmet Christoph

Classifications

• G01R33/24 Primary

  for measuring direction or magnitude of magnetic fields or magnetic flux · CPC title

• G01R33/5676

  Gating or triggering based on an MR signal, e.g. involving one or more navigator echoes for motion monitoring and correction · CPC title