Raft agents and their use in the development of polyvinylpyrrolidone grafted nanoparticles

Patent metadata

Field	Value
Publication number	US-9732169-B2
Application number	US-201514805531-A
Country	US
Kind code	B2
Filing date	Jul 22, 2015
Priority date	Jul 22, 2014
Publication date	Aug 15, 2017
Grant date	Aug 15, 2017

Abstract

Nanoparticles having a plurality of PVP chains covalently bonded to a surface of the nanoparticle are provided, along with their methods of formation and the RAFT agents for the polymerization of the PVP chains. RAFT agents are generally provided, along with their methods of formation and use. Methods are also generally provided for grafting a PVP polymer onto a nanoparticle. In one embodiment, the method includes: polymerizing a plurality of monomers in the presence of a RAFT agent to form a polymeric chain covalently bonded to the nanoparticle.

First claim

What is claimed:

1. A RAFT agent having the formula:

where
R 1 is H or a C 1 to C 5 alkyl group;
R 2 is CN, NO 2 , SO 3 H, or a halogen;
R 3 is a hydroxyl group, a thioazoline group, or OR 4 with R 4 being a C 1 to C 5 alkyl group; and
n is 1 to 12.

2. The RAFT agent of claim 1 , wherein R 1 is H.

3. The RAFT agent of claim 1 , wherein R 2 is a nitrile group.

4. The RAFT agent of claim 1 , wherein n is 2.

5. The RAFT agent of claim 1 , wherein R 3 is a hydroxyl group.

6. The RAFT agent of claims 1 , wherein R 3 is a thioazoline group.

7. A RAFT agent having the formula:

8. A RAFT agent having the formula:

Where
R 1 is H or a C 1 to C 5 alkyl group;
R 2 is CN, NO, SO 3 H, or a halogen; and
n is 1 to 12.

9. The RAFT agent of claim 8 , wherein R 1 is H.

10. The RAFT agent of claim 8 , wherein R 2 is a nitrile group.

11. The RAFT agent of claim 8 , wherein n is 2.

Assignees

• Univ South Carolina

Inventors

• Wang Lei
• Benicewicz Brian C

Classifications

• C08F292/00

  Macromolecular compounds obtained by polymerising monomers on to inorganic materials · CPC title

• C08F2438/03

  Use of a di- or tri-thiocarbonylthio compound, e.g. di- or tri-thioester, di- or tri-thiocarbamate, or a xanthate as chain transfer agent, e.g . Reversible Addition Fragmentation chain Transfer [RAFT] or Macromolecular Design via Interchange of Xanthates [MADIX] · CPC title

• C07D277/16

  Sulfur atoms · CPC title

• C08F126/10 Primary

  N-Vinyl-pyrrolidone · CPC title

• C07D295/194

  Radicals derived from thio- or thiono carboxylic acids · CPC title