Compounds useful as modulators of TRPM8

Patent metadata

Field	Value
Publication number	US-9732071-B2
Application number	US-201615282432-A
Country	US
Kind code	B2
Filing date	Sep 30, 2016
Priority date	Oct 1, 2015
Publication date	Aug 15, 2017
Grant date	Aug 15, 2017

Abstract

The present disclosure relates to compounds which are useful as cooling sensation compounds.

First claim

What is claimed is:

1. A compound selected from the group consisting of

or a salt thereof.

2. The compound of claim 1 having the structure

or a salt thereof.

3. The compound of claim 1 having the structure

or a salt thereof.

4. The compound of claim 1 having the structure

or a salt thereof.

5. The compound of claim 1 having the structure

or a salt thereof.

6. The compound of claim 1 having the structure

or a salt thereof.

7. A composition, comprising a compound of claim 1 and at least one carrier.

8. The composition of claim 7 , wherein the composition is an ingestible composition or personal care product.

9. The composition of claim 7 , wherein the composition is a food or beverage.

10. The composition of claim 7 , wherein the composition is a topical personal care product.

11. The composition of claim 7 , wherein the composition is in form of a solid, semi-solid, plaster, solution, suspension, lotion, cream, foam, gel, paste, or emulsion.

12. The composition of claim 7 , wherein the compound in the composition is in a concentration ranging from about 0.0001 ppm to 100,000 ppm.

13. The composition of claim 7 , wherein the compound in the composition is in a concentration ranging from about 1 ppm to 500 ppm.

14. The composition of claim 7 , which is a textile product or a packaging material.

15. A method of modulating transient receptor potential channel melastatin member 8 (TRPM8) comprising contacting the receptor with a compound of claim 1 .

16. The method of claim 15 , wherein the compound is a TRPM8 receptor agonist.

17. A method of modulating the cooling sensation of a composition comprising combining the composition with a compound of claim 1 to form a modified composition.

18. A method of inducing a cooling sensation in a human or animal comprising contacting the human or animal with a compound of claim 1 .

Assignees

• Senomyx Inc

Inventors

• Patron Andrew P
• Noncovich Alain
• Ung Jane
• Davis Timothy
• Fotsing Joseph R
• Priest Chad
• Tachdjian Catherine

Classifications

• C07D409/12 Primary

  linked by a chain containing hetero atoms as chain links · CPC title

• A61K9/0014

  Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00) · CPC title

• A61K31/4155

  non condensed and containing further heterocyclic rings · CPC title

• B65D65/38

  Packaging materials of special type or form · CPC title

• A23L2/52

  Adding ingredients (adding preservatives A23B70/10) · CPC title