Crush resistant delayed-release dosage forms
US-2015374630-A1 · Dec 31, 2015 · US
US9731437B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9731437-B2 |
| Application number | US-201314087366-A |
| Country | US |
| Kind code | B2 |
| Filing date | Nov 22, 2013 |
| Priority date | Nov 22, 2013 |
| Publication date | Aug 15, 2017 |
| Grant date | Aug 15, 2017 |
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The present invention provides methods for forming an ophthalmic lens that can include a media insert and/or electronic components. In particular, the present disclosure provides for adhesion promoting functionalization steps for a biocompatible coating to bind a hydrogel material to a plastic surface or electronic component prior to the polymerization of the hydrogel. In some aspects, the media insert can be used to contain energy sources and/or functional electronic components which may be, for example, in a stacked integrated component configuration to permit a generally arcuate shape that can conform to the anterior surface of an eye.
Opening claim text (preview).
The invention claimed is: 1. A method of forming an energized ophthalmic device, the method comprising: pre-dosing a first mold part with a pre-dose amount of a reactive monomer mixture; forming a media insert including at least one of energization or functional electronic components formed in a stacked integrated component device configuration, the media insert being a separate component that is configured to mount and encapsulate the at least one energization or functional electronic component; functionalizing the media insert so that an adhesion promoter can bind to a surface of said media insert; applying an adhesion promoter to the functionalized media insert; coating said media insert including the adhesion promoter; placing the media insert on said pre-dose of reactive monomer mixture; pre-curing the pre-dosed reactive monomer mixture to fixedly hold the media insert proximate to the first mold part; post-dosing the first mold part with a post-dose of a reactive monomer mixture; placing a second mold part proximate to the first mold part, wherein the placing forms a ophthalmic device mold assembly with a lens forming cavity; and curing at least the post-dosed reactive monomer mixture to form the ophthalmic lens, wherein the media insert is encapsulated in the ophthalmic lens. 2. The method of claim 1 , wherein the functionalizing step includes providing a plasma treatment in an oxygen environment. 3. The method of claim 1 , wherein the functionalizing step includes exposing the media insert to an ozone environment. 4. The method of claim 1 , wherein the functionalizing step includes crosslinking a chemical with the media insert. 5. The method of claim 4 , wherein the functionalizing step further includes exposing the media insert to a radiation to crosslink said chemical with the media insert. 6. The method of claim 1 , wherein the adhesion promoter includes a methoxy-silane chemical. 7. The method of claim 6 , wherein the methoxy-silane can include one of more of a vinyldimethylethoxysilane, a methoxysilane, a trimethoxysilane, a styrylethyltrimethoxysilane, a bis(trimethoxysilyl)hexane, and a vinylmethoxysiloxane homopolymer. 8. The method of claim 1 , wherein the coating is a parylene coating. 9. The method of claim 1 , wherein the coating is a polymerizable hydrogel coating.
incorporating preformed parts or layers, e.g. casting around inserts or for coating articles {(B29C39/206 takes precedence)} · CPC title
Auxiliary operations, e.g. removing oxygen from the mould, conveying moulds from a storage to the production line in an inert atmosphere · CPC title
of articles of definite length, i.e. discrete articles {(B29C35/0227 takes precedence)} · CPC title
Use of polymers having silicon, with or without sulfur, nitrogen, oxygen, or carbon only, in the main chain, as moulding material · CPC title
Producing lenses combined with electronics, e.g. chips · CPC title
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