Electrospray device

Patent metadata

Field	Value
Publication number	US-9731306-B2
Application number	US-201314424446-A
Country	US
Kind code	B2
Filing date	Aug 28, 2013
Priority date	Aug 28, 2012
Publication date	Aug 15, 2017
Grant date	Aug 15, 2017

Abstract

The invention related to a device ( 1 ) for spraying charged droplets of a liquid towards a target along a spraying direction, comprising: a reservoir ( 10 ) for storing the liquid (L), a first electrode ( 100 ) being arranged at an outlet ( 11 ) of said reservoir ( 10 ), a second electrode ( 200 ) forming a counter electrode to the first electrode ( 100 ) for accelerating said droplets (D) along the spraying direction (S), and a housing ( 30 ) holding the reservoir ( 10 ) as well as said electrodes ( 100, 200 ).

First claim

The invention claimed is:

1. Device for spraying charged droplets of a liquid towards a target along a spraying direction, comprising:
a reservoir ( 10 ) for receiving the liquid (L),
a first electrode ( 100 ) being arranged at an outlet ( 11 ) of said reservoir ( 10 ),
a second electrode ( 200 ) forming a counter electrode to the first electrode ( 100 ) for accelerating said droplets (D) along the spraying direction (S), and
a housing ( 30 ) holding the reservoir ( 10 ) as well as said electrodes ( 100 , 200 ),
wherein said housing ( 30 ) forms a spray chamber ( 31 ) extending along the spraying direction (S), wherein the reservoir ( 10 ) is connected to the spray chamber ( 31 ) via said outlet ( 11 ), and wherein the spray chamber ( 31 ) comprises an opening ( 32 ) facing said outlet ( 11 ) along the spraying direction (S) for electing the droplets (D) out of the spray chamber ( 31 ).

2. Device as claimed in claim 1 , characterized in that an end region ( 200 a ) of the second electrode ( 200 ) is spaced apart from said outlet ( 11 ) along the spraying direction (S).

3. Device as claimed in claim 1 , characterized in that the first electrode ( 100 ) comprises a tubular shape.

4. Device as claimed in claim 1 , characterized in that the first electrode ( 100 ) extends into the spray chamber ( 31 ), wherein the first electrode ( 100 ) comprises a region ( 110 ) arranged on an inside ( 31 a ) of the spray chamber ( 31 ) extending along the spraying direction (S).

5. Device as claimed in claim 1 , characterized in that the second electrode ( 200 ) is arranged at least in sections on a face side ( 10 a ) of the housing ( 30 ) delimiting said opening ( 32 ).

6. Device according to claim 1 , characterized in that the spray chamber ( 31 ) comprises a plurality of lateral through-holes (H) for discharging liquid (L) accumulated in the spray chamber ( 31 ) out of the spray chamber ( 31 ).

7. Device as claimed in claim 1 , characterized in that the second electrode ( 200 ) comprises a contact area ( 200 a ) being designed to contact said target (T) into which said liquid (L) is to be injected.

8. Device according to claim 1 , characterized in that, the second electrode ( 200 ) comprises a circumferential free end region protruding from or out of the spray chamber ( 31 ), which free end region forms a contact area ( 200 a ) being designed to contact said target (T) into which said liquid (L) is to be infected.

9. Device as claimed in claim 1 , characterized in that the second electrode ( 200 ) is arranged within the spray chamber ( 31 ).

10. Device as claimed in claim 1 , characterized in that the second electrode ( 200 ) is arranged along the opening ( 32 ) of the spray chamber ( 31 ), wherein the second electrode ( 200 ) extends circumferentially along the opening ( 32 ) of the spray chamber ( 31 ).

11. Device according to claim 1 , characterized in that the second electrode ( 200 ) or a free end region of the second electrode ( 200 ) protruding from the spray chamber ( 31 ) is designed to be expanded from a first state into a second state and contracted from the second state into the first state, wherein the second electrode ( 200 ) or said free end region comprises a larger diameter in the second state than in the first state, wherein the second electrode ( 200 ) or said free end portion is designed to be expanded from the first into the second state, when the second electrode ( 200 ) or said free end portion is pushed out of a working channel ( 501 ) of a tubular device ( 500 ), wherein the second electrode ( 200 ) or said free end portion is designed to be contracted from the second state into the first state, when the second electrode or said free end portion is pulled into a working channel ( 501 ) of a tubular device ( 500 ), wherein the second electrode ( 200 ) or said free end portion is made of or comprises a flexible, electrically conductive material, wherein the second electrode ( 200 ) or said free end portion is self-expanding or wherein the device ( 1 ) comprises an actuation means for expanding and/or contracting the second electrode ( 200 ) or said free end portion.

12. Device according to claim 1 , characterized in that a connection ( 210 ) of the second electrode ( 200 ) to a voltage source ( 300 ) and/or the second electrode ( 200 ) is shielded from the first electrode ( 100 ) by a shielding ( 400 ), wherein said shielding ( 400 ) is connected to an electrical potential ranging from a potential of the first electrode ( 100 ) up to a potential below the potential of the second electrode ( 200 ).

13. Device according to claim 12 , characterized in that a connection ( 210 ) of the second electrode ( 200 ) to the voltage source ( 300 ) comprises an inner conductor and an outer conductor surrounding the inner conductor, wherein the inner and the outer conductor are arranged coaxially with respect to each other, wherein the second electrode is connected to the respective inner conductor, while the respective outer conductor forming said shielding is connected to a different electrical potential in between the potential of the second electrode and the potential of the first electrode.

14. Device according to claim 12 , characterized in that said shielding ( 400 ) is a cylindrical shielding which surrounds the first electrode ( 100 ) and is coaxially arranged with respect to the first electrode ( 100 ).

15. Device as claimed in claim 1 , characterized in that the spray chamber ( 31 ) comprises at least one window ( 33 ).

16. Device according to claim 1 , characterized in that the second electrode ( 200 ) comprises at least two separate electrode elements ( 200 b - 200 i ), wherein the device ( 1 ) is configured to switch the at least two electrode elements ( 200 b - 200 i ) so as to form a single counter electrode to the first electrode ( 100 ) in order to accelerate said droplets (D), wherein—after having accelerated said droplets (D)—the device ( 1 ) is further designed to apply a potential difference between the at least two electrode elements ( 200 b - 200 i ) for additional electroporation of the droplets (D) injected into the target.

17. Device according to claim 1 , characterized by a voltage source ( 300 ) connected to the first and the second electrode ( 100 , 200 ), which voltage source ( 300 ) is designed to generate a potential difference between the first electrode ( 100 ) and the second electrode ( 200 ) so as to accelerate said droplets (D) towards said target (T), wherein the voltage source ( 300 ) is designed to generate said potential difference as a continuous potential difference or a pulsed potential difference.

18. Device as claimed in claim 1 , characterized in that the device ( 1 ) is configured to set the second electrode ( 200 ) on a potential different from ground and different from the first electrode ( 100 ), so as to enhance electroporation of the droplets (D) injected into the target (T) by increasing a membrane potential of said target (T).

19. Device as claimed in claim 1 , characterized in that the device ( 1 ) comprises a plurality of second electrodes ( 200 ) arranged one after another along the spray chamber ( 31 ) along the spraying direction (S), wherein each two neighboring second electrodes ( 200 ) form a pair (P, P′) of electrodes, wherein the first pair (P) is formed by the first electrode ( 100 ) and a neighboring second electrode ( 200 ) along the spraying direction (S), and wherein the device ( 1 ) is configured to generate a potential difference between said pairs (P, P′) in a sub

Assignees

• Univ Bern
• Fachhochschule Nordwestschweiz Fhnw

Inventors

• Hradetzky David
• Schkommodau Erik
• Bohringer Stephan
• Gazdhar Amiq
• Geiser Thomas

Classifications

• A61M2210/1039

  Lungs · CPC title

• B05B5/087

  Arrangements of electrodes, e.g. of charging, shielding, collecting electrodes (B05B5/12, B05B5/14 take precedence; arrangements of electrodes on the discharge apparatus B05B5/0533) · CPC title

• A61M35/003

  Portable hand-held applicators having means for dispensing or spreading integral media (hand-held massage devices with liquid delivery A61H7/003) · CPC title

• B05B5/0255

  spraying and depositing by electrostatic forces only · CPC title

• A61M15/02

  with activated or ionised {fluids, e.g. electrohydrodynamic [EHD] or electrostatic devices}; Ozone-inhalators {with radioactive tagged particles} · CPC title