SARMs and method of use thereof

Patent metadata

Field	Value
Publication number	US-9730908-B2
Application number	US-201514963054-A
Country	US
Kind code	B2
Filing date	Dec 8, 2015
Priority date	Aug 24, 2006
Publication date	Aug 15, 2017
Grant date	Aug 15, 2017

Abstract

This invention is directed to substituted acylanilide compounds and uses thereof in treating a variety of diseases or conditions in a subject, including, inter alia, a muscle wasting disease and/or disorder such as Duchenne muscular dystrophy or Becker muscular dystrophy.

First claim

What is claimed is:

1. A method of treating, reducing the severity, reducing the incidence, delaying the onset, or reducing the pathogenesis of Duchenne muscular dystrophy in a subject in need thereof, comprising administering to said subject a selective androgen receptor modulator (SARM) compound represented by the structure of formula S-XXIII:

or its optical isomer, pharmaceutically acceptable salt or any combination thereof.

2. The method of claim 1 , wherein said administering comprises administering a pharmaceutical composition comprising said compound and/or its optical isomer, pharmaceutically acceptable salt or any combination thereof; and a pharmaceutically acceptable carrier.

3. The method of claim 1 , wherein said method further increases the physical function of said subject.

4. The method of claim 1 , wherein said method further increases the quality of life of said subject.

5. The method of claim 1 , wherein said method increases the survival of said subject.

6. The method of claim 1 , wherein said method further delays onset or improves symptoms of cardiomyopathy.

7. A method of increasing the physical function of a subject suffering from Duchenne muscular dystrophy, comprising administering to said subject a selective androgen receptor modulator (SARM) compound represented by the structure of formula S-XXIII:

or its optical isomer, pharmaceutically acceptable salt or any combination thereof.

8. A method of increasing the quality of life of a subject suffering from Duchenne muscular dystrophy, comprising administering to said subject a selective androgen receptor modulator (SARM) compound represented by the structure of formula S-XXIII:

or its optical isomer, pharmaceutically acceptable salt or any combination thereof.

9. A method of increasing the survival of a subject suffering from Duchenne muscular dystrophy, comprising administering to said subject a selective androgen receptor modulator (SARM) compound represented by the structure of formula S-XXIII:

or its optical isomer, pharmaceutically acceptable salt or any combination thereof.

10. A method of treating, reducing the severity, reducing the incidence, delaying the onset, or reducing the pathogenesis of cardiomyopathy in a subject suffering from Duchenne muscular dystrophy, comprising administering to said subject a selective androgen receptor modulator (SARM) compound represented by the structure of formula S-XXIII:

or its optical isomer, pharmaceutically acceptable salt or any combination thereof.

11. A method of treating, reducing the severity, reducing the incidence, delaying the onset, or reducing the pathogenesis of Becker muscular dystrophy in a subject in need thereof, comprising administering to said subject a selective androgen receptor modulator (SARM) compound represented by the structure of formula S-XXIII:

or its optical isomer, pharmaceutically acceptable salt or any combination thereof.

12. The method of claim 11 , wherein said administering comprises administering a pharmaceutical composition comprising said compound and/or its optical isomer, pharmaceutically acceptable salt or any combination thereof; and a pharmaceutically acceptable carrier.

13. The method of claim 11 , wherein said method further increases the physical function of said subject.

14. The method of claim 11 , wherein said method further increases the quality of life of said subject.

15. The method of claim 11 , wherein said method further delays onset or improves symptoms of cardiomyopathy.

Assignees

• Univ Tennessee Res Found

Inventors

• Dalton James T
• Miller Duane D
• Ponnusamy Thamarai
• Narayanan Ramesh

Classifications

• C07C255/60

  at least one of the singly-bound nitrogen atoms being acylated · CPC title

• A23K50/80

  for aquatic animals, e.g. fish, crustaceans or molluscs · CPC title

• A23K50/75

  for poultry · CPC title

• A23K50/30

  for swines · CPC title

• A23K20/111

  Aromatic compounds · CPC title