Prophylactic or therapeutic agent for oral diseases

Patent metadata

Field	Value
Publication number	US-9730883-B2
Application number	US-201214236849-A
Country	US
Kind code	B2
Filing date	Aug 3, 2012
Priority date	Aug 5, 2011
Publication date	Aug 15, 2017
Grant date	Aug 15, 2017

Abstract

Provided is a novel lactic acid bacterium strain which is capable of suppressing production of volatile sulfur compounds by oral bacteria, has no cariogenicity and no causative role in infective endocarditis, and is safe in an oral cavity, and provided is an agent for preventing, improving and/or treating oral diseases and discomforts by use of the bacterial strain.
An agent for preventing and/or treating an oral disease, containing, as an active ingredient, at least one lactic acid bacterium selected from Lactobacillus crispatus, Lactobacillus fermentum, Lactobacillus gasseri , and Streptococcus mitis and having all of the following properties (1) to (6):
(1) having no ability to produce a volatile sulfur compound (VSC); (2) having no ability to produce water-insoluble glucan; (3) having adhesiveness to a tooth surface and/or an oral cell; (4) having a growth inhibitory effect on a bad breath-causing bacterium and/or a periodontal pathogen; (5) having no causative role in infective endocarditis; and (6) having no cariogenicity.

First claim

The invention claimed is:

1. A method for inhibiting growth of at least one pathogenic bacterium, the method comprising administering to a subject in need thereof an effective amount of at least one lactic acid bacterium selected from the group consisting of Lactobacillus crispatus YIT 12319 (FERM BP-11500), Lactobacillus fermentum YIT 12320 (FERM BP-11501), Lactobacillus gasseri YIT 12321 (FERM BP-11502), and Streptococcus mitis YIT 12322 (FERM BP-11503),
wherein the at least one pathogenic bacterium is at least one selected from the group consisting of Porphyromonas gingivalis, Prevotella intermedia, Aggregatibacter actinomycetemcomitans, Streptococcus mutans, Streptococcus sobrinus, Fusobacterium nucleatum , and Tannerella forsythia.

2. The method of claim 1 , wherein administering the at least one lactic acid bacterium comprises administering an oral composition comprising the lactic acid bacterium.

3. The method of claim 1 , wherein administering the at least one lactic acid bacterium comprises administering a food or a drink comprising the lactic acid bacterium.

4. The method according to claim 3 , wherein the food or the drink is a fermented product.

5. The method according to claim 1 , wherein the at least one pathogenic bacterium is at least one selected from the group consisting of Porphyromonas gingivalis, Prevotella intermedia, Aggregatibacter actinomycetemcomitans, Streptococcus mutans , and Streptococcus sobrinus.

6. The method according to claim 1 , wherein the at least one pathogenic bacterium is at least one selected from the group consisting of Porphyromonas gingivalis, Fusobacterium nucleatum , and Tannerella forsythia.

7. A method for preventing and/or improving bad breath, the method comprising administering to a subject in need thereof an effective amount of at least one lactic acid bacterium selected from the group consisting of Lactobacillus crispatus YIT 12319 (FERM BP-11500), Lactobacillus fermentum YIT 12320 (FERM BP-11501), Lactobacillus gasseri YIT 12321 (FERM BP-11502), and Streptococcus mitis YIT 12322 (FERM BP-11503).

8. The method of claim 7 , wherein administering the at least one lactic acid bacterium comprises administering a food or a drink comprising the lactic acid bacterium.

9. The method according to claim 8 , wherein the food or the drink is a fermented product.

10. The method of claim 7 , wherein administering the at least one lactic acid bacterium comprises administering an oral composition comprising the lactic acid bacterium.

11. A method for preventing and/or treating gingivitis, the method comprising administering to a subject in need thereof an effective amount of at least one lactic acid bacterium selected from the group consisting of Lactobacillus crispatus YIT 12319 (FERM BP-11500), Lactobacillus fermentum YIT 12320 (FERM BP-11501), Lactobacillus gasseri YIT 12321 (FERM BP-11502), and Streptococcus mitis YIT 12322 (FERM BP-11503).

12. The method of claim 11 , wherein administering the at least one lactic acid bacterium comprises administering a food or a drink comprising the lactic acid bacterium.

13. The method according to claim 12 , wherein the food or the drink is a fermented product.

14. The method of claim 11 , wherein administering the at least one lactic acid bacterium comprises administering an oral composition comprising the lactic acid bacterium.

15. A method for improving bad breath, the method comprising administering to a subject in need thereof an effective amount of at least one lactic acid bacterium selected from the group consisting of Lactobacillus crispatus YIT 12319 (FERM BP-11500), Lactobacillus fermentum YIT 12320 (FERM BP-11501), Lactobacillus gasseri YIT 12321 (FERM BP-11502), and Streptococcus mitis YIT 12322 (FERM BP-11503).

16. The method of claim 15 , wherein administering the at least one lactic acid bacterium comprises administering a food or a drink comprising the lactic acid bacterium.

17. The method according to claim 16 , wherein the food or the drink is a fermented product.

18. The method of claim 15 , wherein administering the at least one lactic acid bacterium comprises administering an oral composition comprising the lactic acid bacterium.

19. A method for treating gingivitis, the method comprising administering to a subject in need thereof an effective amount of at least one lactic acid bacterium selected from the group consisting of Lactobacillus crispatus YIT 12319 (FERM BP-11500), Lactobacillus fermentum YIT 12320 (FERM BP-11501), Lactobacillus gasseri YIT 12321 (FERM BP-11502), and Streptococcus mitis YIT 12322 (FERM BP-11503).

20. The method of claim 19 , wherein administering the at least one lactic acid bacterium comprises administering a food or a drink comprising the lactic acid bacterium.

21. The method according to claim 20 , wherein the food or the drink is a fermented product.

22. The method of claim 19 , wherein administering the at least one lactic acid bacterium comprises administering an oral composition comprising the lactic acid bacterium.

Assignees

• Okumura Takekazu
• Terai Tomohiko
• Nakao Masumi
• Kaneko Kimiyuki
• Ito Masahiko
• Miyazaki Kouji
• Yamaji Kazuaki
• Tochiya Kaoru
• Hanada Nobuhiro
• Imai Susumu
• Nomura Yoshiaki
• Baba Shunsuke
• Yakult Honsha Kk

Inventors

• Okumura Takekazu
• Terai Tomohiko
• Nakao Masumi
• Kaneko Kimiyuki
• Ito Masahiko
• Miyazaki Kouji
• Yamaji Kazuaki
• Tochiya Kaoru
• Hanada Nobuhiro
• Imai Susumu
• Nomura Yoshiaki
• Baba Shunsuke

Classifications

• A61K9/2018

  Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates · CPC title

• A61Q11/00

  Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses · CPC title

• A61K35/747

  Lactobacilli, e.g. L. acidophilus or L. brevis · CPC title

• C12N1/20

  Bacteria; Culture media therefor · CPC title

• A23L2/52

  Adding ingredients (adding preservatives A23B70/10) · CPC title