Novel chondrocyte induction method
US-2016251623-A1 · Sep 1, 2016 · US
Chondrogenic progenitor cells, protocol for derivation of cells and uses thereof
US9725697B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9725697-B2 |
| Application number | US-201514708606-A |
| Country | US |
| Kind code | B2 |
| Filing date | May 11, 2015 |
| Priority date | Apr 8, 2010 |
| Publication date | Aug 8, 2017 |
| Grant date | Aug 8, 2017 |
How to read this patent
A practical reading order for non-experts. Skip the full description unless you need deep technical detail.
- Title
What the patent document calls the invention.
- Abstract
A short plain-language summary of the technical disclosure.
- Assignees and inventors
Who owns or filed the patent and who is credited as inventor.
- Key dates
Filing, priority, publication, and grant dates set the timeline.
- First independent claim
The legal scope of protection — read this for what is actually claimed.
- CPC / IPC classifications
Technology tags used to group this patent with similar filings.
- Citations and related patents
Prior art links and similar publications in this corpus.
Abstract
Official abstract text for this publication.
The present invention provides an isolated population of chondrocyte precursor cells wherein 1% or less of the cells express Oct4, Nanog and/or TRA-1-60, 7% or less of the cells express no collagen II, collagen X, CD105 or Stro-1 and 85% or more of the cells express CBFA1, methods for preparing such cells and uses of chondrocyte cells derived from said precursor cells.
First claim
Opening claim text (preview).
The invention claimed is: 1. A population of de-differentiated committed chondrocyte precursor cells, wherein the de-differentiated committed chondrocyte precursor cells are the in vitro progeny of human embryonic stem (hES) cells and characterized by 85% or more of the cells expressing CBFA1 and by the loss of transdifferentiation potential to form osteoblasts when cultured in osteogenic medium. 2. The population of claim 1 , wherein 1% or less of the cells express Oct4, Nanog and/or TRA-1-60. 3. The population of claim 1 , wherein 1% or less of the cells express Ki67. 4. The population of claim 1 , further comprising human embryonic stem (hES) cells, wherein the de-differentiated committed chondrocyte precursor cells are the in vitro progeny of the hES cells. 5. A first and a second population of cells, comprising: a) a first in vitro population of cells comprising human embryonic stem (hES) cells; and b) a second in vitro population of cells comprising de-differentiated committed chondrocyte precursor (DDPC) cells that are the progeny of the hES cells, wherein 85% or more of the DDPCs express CBFA1 and wherein the DDPCs are characterized by the loss of transdifferentiation potential to form osteoblasts when cultured in osteogenic medium.
Assignees
Inventors
Classifications
from embryonic cells · CPC title
Transforming growth factor beta (TGF-β) · CPC title
for joint disorders, e.g. arthritis, arthrosis · CPC title
- C12N5/0655Primary
Chondrocytes; Cartilage · CPC title
Steroid hormones · CPC title
Patent family
Related publications grouped by family.
External sources
Frequently asked questions
Answers are generated from the same data shown on this page.
- What does patent US9725697B2 cover?
- The present invention provides an isolated population of chondrocyte precursor cells wherein 1% or less of the cells express Oct4, Nanog and/or TRA-1-60, 7% or less of the cells express no collagen II, collagen X, CD105 or Stro-1 and 85% or more of the cells express CBFA1, methods for preparing such cells and uses of chondrocyte cells derived from said precursor cells.
- Who is the assignee on this patent?
- Univ Court Univ Of Edinburgh
- What technology area does this patent fall under?
- Primary CPC classification C12N5/0655. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Aug 08 2017 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).