Pharmaceutical composition for preventing or treating hyperlipidemia

Patent metadata

Field	Value
Publication number	US-9724336-B2
Application number	US-201214361371-A
Country	US
Kind code	B2
Filing date	Nov 28, 2012
Priority date	Nov 30, 2011
Publication date	Aug 8, 2017
Grant date	Aug 8, 2017

Abstract

Provided is a pharmaceutical composition for preventing or treating hyperlipidemia comprising (4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-({2-[4-fluoro-2-methoxy-5-(propan-2-yl)phenyl]-5-(trifluoromethyl)phenyl}methyl)-4-methyl-1,3-oxazolidin-2-one or its pharmaceutically acceptable salt; and an angiotensin II receptor blocker as active ingredients.

First claim

The invention claimed is:

1. A method for treating hypertriglyceridemia, hypertriglyceridemia-associated atherosclerosis or hypertriglyceridemia-associated pancreatitis in a patient, which comprises administering a therapeutically effective amount of a compound of Formula 1 or its pharmaceutically acceptable salt in combination with a therapeutically effective amount of olmesartan medoxomil or its pharmaceutically acceptable salt to the patient in need thereof,
wherein the combination is synergistic in treating the hypertriglyceridemia, hypertriglyceridemia-associated atherosclerosis or hypertriglyceridemia-associated pancreatitis, and the compound of Formula 1 or its pharmaceutically acceptable salt is administered in a dose of 20 mg/kg/day and the olmesartan medoxomil or its pharmaceutically acceptable salt is administered in a dose of 3 mg/kg/day:

2. The method according to claim 1 , wherein the administering is carried out with a dosage form for oral administration.

Assignees

• Dae Woong Pharma

Inventors

• Lee Jong-Wook
• Lee Sang-Ho
• Lim Taek-Joo
• Koh Eun-Ji

Classifications

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P7/00

  Drugs for disorders of the blood or the extracellular fluid · CPC title

• A61P9/12

  Antihypertensives · CPC title

• A61P3/06

  Antihyperlipidemics · CPC title

• A61P9/10

  for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis · CPC title