Composition and method for compounded therapy

Patent metadata

Field	Value
Publication number	US-9724294-B2
Application number	US-201213564525-A
Country	US
Kind code	B2
Filing date	Aug 1, 2012
Priority date	Dec 27, 2011
Publication date	Aug 8, 2017
Grant date	Aug 8, 2017

Abstract

The present embodiments relate to topically delivered compounded medications. A transdermal cream may provide the effective topical administration of multiple medications simultaneously. The transdermal cream may include low concentrations of local anesthetics, a NSAID, an anticonvulsant, and/or other active ingredients. For instance, the transdermal cream may include lidocaine, prilocaine, meloxicam, and lamotrigine and/or topiramate. Alternatively, the transdermal cream may include a lidocaine/prilocaine base cream to which is added a fine powder of one or more ground up medications to form a compounded medication. The compounded medication in powder form may be generated from grinding up tablets of NSAIDs, anticonvulsants, nerve depressants, antidepressants, muscle relaxants, NMDA receptor antagonists, opiate or opioid agonists, and/or other agents. The compounded medication in powder form may include meloxicam, lamotrigine, topiramate, and/or other active ingredients. In another aspect, the present embodiments relate to methods of compounding medications and transdermal creams or gels.

First claim

What is claimed is:

1. A compounded transdermal cream that permits the simultaneous administration of multiple medications in low concentrations prepared by a process comprising:
wetting a fine powder comprising one or more ground meloxicam tablets with DMSO;
wetting a fine powder comprising one or more ground lamotrigine tablets with DMSO; and
combining the wetted fine powders with a lidocaine 2.5% and prilocaine 2.5% cream,
wherein the lidocaine 2.5% and prilocaine 2.5% cream is combined in an amount of at least 60% lidocaine 2.5% and prilocaine 2.5% cream by weight of the transdermal cream,
wherein the fine powder comprising the one or more ground meloxicam tablets is combined in an amount between 0.01% and 5.0% meloxicam by weight of the transdermal cream, and
wherein the fine powder comprising the one or more ground lamotrigine tablets is combined in an amount between 0.5% and 5.0% lamotrigine by weight of the transdermal cream.

2. The transdermal cream of claim 1 , wherein the amount of meloxicam is between 0.05% and 0.2% by weight of the transdermal cream.

3. The transdermal cream of claim 2 , wherein the amount of lamotrigine is between 2.0% and 3.0% by weight of the transdermal cream.

4. The transdermal cream of claim 3 , wherein the amount of meloxicam is 0.09% by weight of the transdermal cream, the amount of lamotrigine is 2.5% by weight of the transdermal cream, and the amount of lidocaine 2.5% and prilocaine 2.5% cream is 80% by weight of the transdermal cream.

5. The transdermal cream of claim 4 , wherein when stored at room temperature for six months, the compounded transdermal cream maintains at least 95% of the starting concentration of each of meloxicam, lamotrigine, lidocaine, and prilocaine.

6. The transdermal cream of claim 4 , wherein the transdermal cream can be stored at room temperature for 100 days and avoid degradation of the active ingredients.

7. A method of compounding medication with a transdermal cream for the topical administration of a compounded therapy, the method comprising:
grinding up one or more tablets of meloxicam into a fine powder;
grinding up one or more tablets of lamotrigine into a fine powder;
wetting the fine powders with DMSO;
adding the wetted fine powders to a lidocaine 2.5% and prilocaine 2.5% cream; and
mixing the added fine powders with the lidocaine 2.5% and prilocaine 2.5% cream to obtain a compounded transdermal cream, wherein the compounded transdermal cream comprises at least 60% by weight lidocaine 2.5% and prilocaine 2.5% cream, and wherein the fine powders are added to the lidocaine 2.5% and prilocaine 2.5% cream in amounts sufficient to obtain between 0.01% and 5.0% by weight meloxicam in the compounded transdermal cream and between 0.5% and 5.0% by weight lamotrigine in the compounded transdermal cream.

8. The method of claim 7 , wherein fine powder of meloxicam is added to the lidocaine 2.5% and prilocaine 2.5% cream in a sufficient amount such that the meloxicam is between 0.05% and 0.15% by weight of the compounded transdermal cream.

9. The method of claim 7 , wherein the fine powder of lamotrigine is added to the lidocaine 2.5% and prilocaine 2.5% cream in a sufficient amount such that the lamotrigine is between 2.0% and 3.0% by weight of the compounded transdermal cream.

10. The method of claim 7 , wherein the fine powders are added to the lidocaine 2.5% and prilocaine 2.5% cream in sufficient amounts such that the meloxicam is in a low amount of between 0.05% and 0.15% by weight of the compounded transdermal cream and lamotrigine is in a low amount of between 2.0% and 3.0% by weight of the compounded transdermal cream.

11. The method of claim 7 , wherein the fine powders are added to lidocaine 2.5% and prilocaine 2.5% cream in sufficient amounts such that the compounded transdermal cream consists essentially of lidocaine, prilocaine, meloxicam, and lamotrigine, wherein (1) the lidocaine 2.5% and prilocaine 2.5% cream is in an amount between 60% and 80% by weight of the compounded transdermal cream (2) meloxicam is in an amount between 0.05% and 0.15% by weight of the compounded transdermal cream, and (3) lamotrigine is in an amount between 2.0% and 3.0% by weight of the compounded transdermal cream.

12. A method of making a compounded transdermal cream, the method comprising:
grinding up tablets of meloxicam into a fine powder;
grinding up tablets of lamotrigine, topiramate, or combination thereof into a fine powder;
wetting the fine powders with DMSO;
adding the wetted fine powders to a lidocaine 2.5% and prilocaine 2.5% cream; and mixing the added wetted fine powders and the lidocaine 2.5% and prilocaine 2.5% cream to obtain a compounded transdermal cream, wherein the compounded transdermal cream comprises 0.01% to 5.0% by weight meloxicam, 0.5% to 5.0% by weight lamotrigine, topiramate, or a combination thereof, and at least 60% lidocaine 2.5% and prilocaine 2.5% cream.

13. The compounded transdermal cream of claim 3 , wherein the amount of lidocaine 2.5% and prilocaine 2.5% cream is 80% by weight of the transdermal cream.

Assignees

• Ray Ii Jay Richard
• Hodge Charles D
• Cmpd Licensing Llc

Inventors

• Ray Ii Jay Richard
• Hodge Charles D

Classifications

• A61P29/00

  Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] · CPC title

• A61P25/24

  Antidepressants · CPC title

• A61P25/08

  Antiepileptics; Anticonvulsants · CPC title

• A61P25/04

  Centrally acting analgesics, e.g. opioids · CPC title

• A61K31/7048

  having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin {, digitoxin or digoxin} · CPC title