Aneurysm closure clip

Patent metadata

Field	Value
Publication number	US-9724104-B2
Application number	US-201214241921-A
Country	US
Kind code	B2
Filing date	Aug 30, 2012
Priority date	Sep 1, 2011
Publication date	Aug 8, 2017
Grant date	Aug 8, 2017

Abstract

An aneurysm closure clip along with a system and method for use by a physician in delivering the closure clip into the vasculature of a patient is disclosed. The closure clip delivery system comprises a delivery tube in the form of a catheter, a guide wire, and a detachable closure clip. The closure clip includes a proximal side and a distal side. The distal side comprises at least two winged elements that interact with the wall of the body vessel to hold the clip in place after delivery. The proximal side includes a seal element and a guide bar. The guide bar is in communication with the guide wire during delivery. The seal element forms a barrier between the aneurysm and the rest of the body vessel, thereby, reducing any pressure exerted on the aneurysm. The seal element and optionally the winged elements include a material layer comprised of bioremodelable material, such as an extracellular matrix material (ECM).

First claim

What is claimed is:

1. An aneurysm closure clip for treating an aneurysm in a body vessel of a patient, the closure clip comprising:
a self-expanding frame having a proximal side and a distal side with respect to a delivery position in a target location, in which the proximal side is disposed inside a blood vessel and the distal side is disposed in an aneurism formed in a wall of the blood vessel; the frame configured to move between a collapsed state in which the proximal and distal sides are compressed for delivery and an expanded state in which the frame expands to engage the blood vessel;
wherein the distal side includes at least two winged elements; each winged element configured to be inserted into the aneurism and adapted to interact with the inner wall of the body vessel in order to secure the closure clip proximate to the aneurysm;
wherein the proximal side includes a seal element and a guide bar; the seal element adapted to separate the aneurysm from the rest of the body vessel and to reduce the pressure exerted on the walls of the body vessel proximate to the aneurysm; the guide bar configured to be in communication with a guide wire during delivery of the closure clip to the aneurysm,
a connector, retention member, or wire, forming two connector points on laterally opposite sides of the seal element,
wherein in each of the two connector points, the seal element and the at least two winged elements are all joined together, and
wherein the at least two winged elements and the seal element are all separate from one another outside of the connector points.

2. The closure clip of claim 1 , wherein the frame is comprised of one selected from the group of stainless steel and a superelastic material.

3. The closure clip of claim 1 , wherein the frame has a closed circumference.

4. The closure clip of claim 3 , wherein the frame is constructed of at least one coil with one or more wires run through the orifice of coil;
wherein the ends of the wires interact with one another such that the coils form the winged elements and seal element.

5. The closure clip of claim 1 , wherein the frame includes a surface treatment or coating of a therapeutic agent.

6. The closure clip of claim 1 , wherein the seal element includes a material layer comprising an extracellular matrix (ECM).

7. The closure clip of claim 6 , wherein the extracellular matrix is comprised of small intestinal submucosa (SIS).

8. The closure clip of claim 1 , wherein at least one of the winged elements further comprises a material layer; the material layer being an extracellular matrix (ECM).

9. The closure clip of claim 8 , wherein the extracellular matrix is comprised of small intestinal submucosa (SIS).

10. The closure clip of claim 1 , wherein the frame further comprises at least one selected from the group of one or more barbs to anchor the frame to the body vessel and a radiopaque or echogenic marker band to assist in locating the closure clip in the body vessel.

11. A method for delivering a closure clip to a targeted location in a body vessel proximate to an aneurysm; the method comprising the steps of:
introducing a delivery catheter having a proximal and distal end into the body vessel; the distal end being located proximate to the targeted location in the body vessel;
providing a closure clip; the closure clip comprising:
a self-expanding frame having a proximal side and a distal side with respect to a delivery position in a target location, in which the proximal side is disposed inside a blood vessel and the distal side is disposed in an aneurism formed in a wall of the blood vessel; the frame configured to move between a collapsed state in which the proximal and distal sides are compressed for delivery and an expanded state in which the frame expands to engage the blood vessel;
the distal side including at least two winged elements; each winged element configured to be inserted into the aneurism and adapted to interact with the inner wall of the body vessel in order to secure the closure clip proximate to the aneurysm; and
the proximal side including a seal element and a guide bar; the seal element adapted to separate the aneurysm from the rest of the body vessel and to reduce the pressure exerted on the walls of the body vessel proximate to the aneurysm; the guide bar configured to be in communication with a guide wire during delivery of the closure clip to the aneurysm in the body vessel;

wherein the seal element and the at least two winged elements are all joined together by a connector, retention member, or wire forming two connector points on laterally opposite sides of the seal element,
wherein in each of the two connector points, the seal element and the at least two winged elements are all joined together,

inserting the closure clip in the collapsed state into the proximal end of the delivery catheter;
inserting an end of a guide wire into the proximal end of the delivery catheter; the end of the guide wire adapted to make reversible contact with the guide bar; the guide wire adapted to move the closure clip through the delivery catheter;
delivering the closure clip to the targeted location in the body vessel; and
allowing the closure clip to move to the expanded state for engagement with the body vessel.

12. The method of claim 11 , wherein the step of allowing the closure clip to move to the expanded state for engagement with the body vessel includes the winged elements and seal elements contacting the inner wall of the body vessel in order to form a barrier between the aneurysm and the rest of the body vessel.

13. A closure clip delivery system used by a physician to deliver a closure clip to a targeted location proximate to an aneurysm in the vasculature of a patient; the closure clip delivery system comprising:
a delivery catheter having a proximal end and a distal end, the catheter inserted into the vasculature of the patient;
a guide wire through which the physician can manipulate the closure clip during delivery of the clip to the targeted location; and
a detachable closure clip, the closure clip comprising:
a self-expanding frame having a proximal side and a distal side with respect to a delivery position in a target location, in which the proximal side is disposed inside a blood vessel and the distal side is disposed in an aneurism formed in a wall of the blood vessel; the frame configured to move between a collapsed state in which the proximal and distal sides are compressed for delivery and an expanded state in which the frame expands to engage the blood vessel;
the distal side including at least two winged elements; each winged element configured to be inserted into the aneurism and adapted to interact with the inner wall of the body vessel in order to secure the closure clip proximate to the aneurysm; and
the proximal side including a seal element and a guide bar; the seal element adapted to separate the aneurysm from the rest of the body vessel and to reduce the pressure exerted on the walls of the body vessel proximate to the aneurysm; the guide bar configured to be in communication with a guide wire during delivery of the closure clip to the aneurysm in the body vessel,

a connector, retention member, or wire, forming two connector points on laterally opposite sides of the seal element,
wherein in each of the two connector points, the seal element and the at least two winged elements are all joined together, and
wherein the at least two winged elements and the seal element are all separate from one another outside of the connector points.

14. The closure clip delivery system of claim 13 , wherein at least one

Assignees

• Tekulve Kurt J
• Theobald Elizabeth A
• Harris Steve
• Cook Medical Technologies Llc

Inventors

• Tekulve Kurt J
• Theobald Elizabeth A
• Harris Steve

Classifications

• A61B17/122

  Clamps or clips, e.g. for the umbilical cord {(for the vas deferens A61F6/206)} · CPC title

• A61B17/12022 Primary

  Occluding by internal devices, e.g. balloons or releasable wires (plugging an opening in the wall of an organ A61B17/0057; occluders for the cervical canal A61F6/146; vas deferens occluders A61F6/20) · CPC title

• A61B2017/12054

  Details concerning the detachment of the occluding device from the introduction device · CPC title

• A61B17/12113

  within an aneurysm · CPC title

• A61B17/1215

  comprising additional materials, e.g. thrombogenic, having filaments, having fibers, being coated · CPC title